Document Detail

Daily variations in pineal melatonin concentrations in inbred and outbred mice.
MedLine Citation:
PMID:  9783231     Owner:  NLM     Status:  MEDLINE    
Melatonin was measured using a specific radioimmunoassay in 1 strain of outbred mice (OF1 Swiss) and 4 strains of inbred mice, 2 of them being known to synthesize melatonin (CBA and C3H) and the 2 others being controversial (BALB/c and C57BL/6). In this study, the 5 mouse strains were able to synthesize melatonin, but the basal levels as well as the diurnal variations were very different from one strain to another. CBA and C3H strains showed a clear-cut day-night rhythm of pineal melatonin concentration, with peak levels of 276 +/- 22 pg/pineal in CBA and 135 +/- 12 pg/pineal in C3H. In BALB/c, the authors confirmed the presence of a very short melatonin peak (15 min) in the middle of the dark period. In C57BL/6 and OF1 Swiss, a very small but significant peak was observed in the middle of the darkness. In the former, another small peak was also observed at light onset. Whether these very small peaks, which may be related to the deficience of N-acetyl transferase activity reported by others, have a physiological meaning remains to be determined.
B Vivien-Roels; A Malan; M C Rettori; P Delagrange; J P Jeanniot; P Pévet
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biological rhythms     Volume:  13     ISSN:  0748-7304     ISO Abbreviation:  J. Biol. Rhythms     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-12-18     Completed Date:  1998-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8700115     Medline TA:  J Biol Rhythms     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  403-9     Citation Subset:  IM    
UMR CNRS 7518, Université Louis Pasteur, Strasbourg, France.
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MeSH Terms
Circadian Rhythm / physiology*
Gas Chromatography-Mass Spectrometry
Melatonin / metabolism*
Mice / metabolism*
Mice, Inbred Strains
Osmolar Concentration
Pineal Gland / metabolism*
Reg. No./Substance:

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