Document Detail


Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism.
MedLine Citation:
PMID:  19306018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hepcidin and hemojuvelin (HJV) are two critical regulators of iron metabolism as indicated by the development of major iron overload associated to mutations in hepcidin and HJV genes. Hepcidin and HJV are highly expressed in liver and muscles, respectively. Intensive muscular exercise has been reported to modify serum iron parameters and to increase hepcidinuria. The present study aimed at evaluating the potential impact of low intensity muscle exercise on iron metabolism and on hepcidin, its key regulator. Fourteen normal volunteers underwent submaximal cycling-based exercise in a crossover design and various iron parameters, including serum and urinary hepcidin, were serially studied. The results demonstrated that submaximal ergocycle endurance exercise did not modulate hepcidin. This study also indicated that hepcidinuria did not show any daily variation whereas serum hepcidin did. The findings, by demonstrating that hepcidin concentrations are not influenced by submaximal cycling exercise, may have implications for hepcidin sampling in medical practice.
Authors:
Marie-Bérengère Troadec; Fabrice Lainé; Vincent Daniel; Pierre Rochcongar; Martine Ropert; Florian Cabillic; Michèle Perrin; Jeff Morcet; Olivier Loréal; Gordana Olbina; Mark Westerman; Elizabeta Nemeth; Tomas Ganz; Pierre Brissot
Related Documents :
9129268 - Exercise immunology: practical applications.
1996568 - Reactive oxygen species production by monocytes and polymorphonuclear leukocytes during...
1903318 - Selective uptake of glutamine in the gastrointestinal tract: confirmation in a human st...
12972438 - Carbohydrate intake during endurance exercise increases natural killer cell responsiven...
3930248 - The time of onset of action of sublingual nitroglycerin in exercise-induced angina pect...
19597418 - A controlled randomized study examining the effects of exercise therapy on patients und...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-21
Journal Detail:
Title:  European journal of applied physiology     Volume:  106     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-01     Completed Date:  2009-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  435-43     Citation Subset:  IM    
Affiliation:
Liver Disease Unit, Inserm U-522, IFR 140, University Hospital Pontchaillou, Rennes, France. marie-berengere.troadec@path.utah.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antimicrobial Cationic Peptides / blood*,  urine*
Exercise / physiology*
Humans
Iron / metabolism*
Iron Overload / metabolism
Iron, Dietary
Metabolic Networks and Pathways
Chemical
Reg. No./Substance:
0/Antimicrobial Cationic Peptides; 0/Iron, Dietary; 0/hepcidin; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Chronic resistance training decreases MuRF-1 and Atrogin-1 gene expression but does not modify Akt, ...
Next Document:  Acute effects of localized muscle fatigue on postural control and patterns of recovery during uprigh...