Document Detail

Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism.
MedLine Citation:
PMID:  19306018     Owner:  NLM     Status:  MEDLINE    
Hepcidin and hemojuvelin (HJV) are two critical regulators of iron metabolism as indicated by the development of major iron overload associated to mutations in hepcidin and HJV genes. Hepcidin and HJV are highly expressed in liver and muscles, respectively. Intensive muscular exercise has been reported to modify serum iron parameters and to increase hepcidinuria. The present study aimed at evaluating the potential impact of low intensity muscle exercise on iron metabolism and on hepcidin, its key regulator. Fourteen normal volunteers underwent submaximal cycling-based exercise in a crossover design and various iron parameters, including serum and urinary hepcidin, were serially studied. The results demonstrated that submaximal ergocycle endurance exercise did not modulate hepcidin. This study also indicated that hepcidinuria did not show any daily variation whereas serum hepcidin did. The findings, by demonstrating that hepcidin concentrations are not influenced by submaximal cycling exercise, may have implications for hepcidin sampling in medical practice.
Marie-Bérengère Troadec; Fabrice Lainé; Vincent Daniel; Pierre Rochcongar; Martine Ropert; Florian Cabillic; Michèle Perrin; Jeff Morcet; Olivier Loréal; Gordana Olbina; Mark Westerman; Elizabeta Nemeth; Tomas Ganz; Pierre Brissot
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-21
Journal Detail:
Title:  European journal of applied physiology     Volume:  106     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-01     Completed Date:  2009-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  435-43     Citation Subset:  IM    
Liver Disease Unit, Inserm U-522, IFR 140, University Hospital Pontchaillou, Rennes, France.
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MeSH Terms
Antimicrobial Cationic Peptides / blood*,  urine*
Exercise / physiology*
Iron / metabolism*
Iron Overload / metabolism
Iron, Dietary
Metabolic Networks and Pathways
Reg. No./Substance:
0/Antimicrobial Cationic Peptides; 0/Iron, Dietary; 0/hepcidin; 7439-89-6/Iron

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