Document Detail

Daily profile of plasma endothelin-1 and -3 in pre-ascitic cirrhosis: relationships with the arterial pressure and renal function.
MedLine Citation:
PMID:  9126793     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Measurements of plasma endothelin-1 and -3 in pre-ascitic cirrhosis have provided controversial results. Similarly, the role of the endothelin system in the pathogenesis of volume and hemodynamic disturbances of cirrhosis is still debated. To provide a further insight into this issue, we assessed the daily fluctuations of plasma endothelins and their relationship with arterial pressure and renal function in pre-ascitic cirrhosis. METHODS: Endothelin-1 and -3, plasma renin activity, atrial natriuretic peptide, noradrenaline and mean arterial pressure were measured at 11 pm, 7 am, 9 am and 6 pm in 10 patients with pre-ascitic cirrhosis and in 10 healthy subjects on normal sodium diet and carrying on their usual activities (supine from 10 pm to 7 am, standing and mobile after 7 am). Glomerular filtration rate and daily renal sodium excretion were assessed during the supine period, and from 7 am to 12 am and from 12 am to 10 pm during the standing period. RESULTS: Endothelin-1 was higher in patients than in control subjects (p=0.000) and did not change during the study. Endothelin-3 was also higher in patients (p=0.002) and showed slight fluctuation in control subjects. The mean daily level of plasma renin activity was lower (p=0.016) and that of atrial natriuretic peptide higher (p=0.000) in patients with cirrhosis. Norepinephrine and mean arterial pressure did not differ significantly between the two groups. No correlations were found between endothelins and either hemodynamic or neuro-hormonal and renal function parameters in the two groups. CONCLUSIONS: Despite the presence of increased effective volemia (as suggested by the reduced plasma renin activity and elevated atrial natriuretic peptide) and normal adrenergic tone, patients with pre-ascitic cirrhosis show elevated levels of endothelin-1 and endothelin-3 throughout the day. In early cirrhosis circulating endothelins, although elevated, do not appear to play a more prominent role in setting arterial pressure than in normal subjects, and endothelin elevation is not detrimental to renal function.
F Trevisani; A Colantoni; A L Gerbes; V Gülberg; G Sica; P Caraceni; S De Notariis; A M Morselli-Labate; A Ligabue; G Gasbarrini; M Bernardi
Related Documents :
8179853 - Renal proliferative and phenotypic changes in rats with two-kidney, one-clip goldblatt ...
2681593 - Clinical pharmacological evaluation of calcium antagonists and other drugs modifying my...
10981553 - Beta2-adrenergic receptor polymorphisms at codon 16, cardiovascular phenotypes and esse...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hepatology     Volume:  26     ISSN:  0168-8278     ISO Abbreviation:  J. Hepatol.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-07-30     Completed Date:  1997-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  808-15     Citation Subset:  IM    
Department of Internal Medicine, Cardioangiology, Hepatology, University of Bologna, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Ascites / etiology
Atrial Natriuretic Factor / blood
Blood Pressure
Circadian Rhythm*
Endothelin-1 / blood*
Endothelin-3 / blood*
Glomerular Filtration Rate
Kidney / physiopathology
Liver Cirrhosis / blood*,  complications,  physiopathology
Middle Aged
Norepinephrine / blood
Renin / blood
Reg. No./Substance:
0/Endothelin-1; 0/Endothelin-3; 51-41-2/Norepinephrine; 85637-73-6/Atrial Natriuretic Factor; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Evidence that "myofibroblast-like" cells are the cellular source of capsular collagen in hepatocellu...
Next Document:  Octreotide long-term treatment in patients with portal hypertension: persistent inhibition of postpr...