| Daily profile of plasma endothelin-1 and -3 in pre-ascitic cirrhosis: relationships with the arterial pressure and renal function. | |
MedLine Citation:
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PMID: 9126793 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Measurements of plasma endothelin-1 and -3 in pre-ascitic cirrhosis have provided controversial results. Similarly, the role of the endothelin system in the pathogenesis of volume and hemodynamic disturbances of cirrhosis is still debated. To provide a further insight into this issue, we assessed the daily fluctuations of plasma endothelins and their relationship with arterial pressure and renal function in pre-ascitic cirrhosis. METHODS: Endothelin-1 and -3, plasma renin activity, atrial natriuretic peptide, noradrenaline and mean arterial pressure were measured at 11 pm, 7 am, 9 am and 6 pm in 10 patients with pre-ascitic cirrhosis and in 10 healthy subjects on normal sodium diet and carrying on their usual activities (supine from 10 pm to 7 am, standing and mobile after 7 am). Glomerular filtration rate and daily renal sodium excretion were assessed during the supine period, and from 7 am to 12 am and from 12 am to 10 pm during the standing period. RESULTS: Endothelin-1 was higher in patients than in control subjects (p=0.000) and did not change during the study. Endothelin-3 was also higher in patients (p=0.002) and showed slight fluctuation in control subjects. The mean daily level of plasma renin activity was lower (p=0.016) and that of atrial natriuretic peptide higher (p=0.000) in patients with cirrhosis. Norepinephrine and mean arterial pressure did not differ significantly between the two groups. No correlations were found between endothelins and either hemodynamic or neuro-hormonal and renal function parameters in the two groups. CONCLUSIONS: Despite the presence of increased effective volemia (as suggested by the reduced plasma renin activity and elevated atrial natriuretic peptide) and normal adrenergic tone, patients with pre-ascitic cirrhosis show elevated levels of endothelin-1 and endothelin-3 throughout the day. In early cirrhosis circulating endothelins, although elevated, do not appear to play a more prominent role in setting arterial pressure than in normal subjects, and endothelin elevation is not detrimental to renal function. |
Authors:
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F Trevisani; A Colantoni; A L Gerbes; V Gülberg; G Sica; P Caraceni; S De Notariis; A M Morselli-Labate; A Ligabue; G Gasbarrini; M Bernardi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hepatology Volume: 26 ISSN: 0168-8278 ISO Abbreviation: J. Hepatol. Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-07-30 Completed Date: 1997-07-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8503886 Medline TA: J Hepatol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 808-15 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Cardioangiology, Hepatology, University of Bologna, Italy. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Ascites / etiology Atrial Natriuretic Factor / blood Blood Pressure Circadian Rhythm* Endothelin-1 / blood* Endothelin-3 / blood* Female Glomerular Filtration Rate Humans Kidney / physiopathology Liver Cirrhosis / blood*, complications, physiopathology Male Middle Aged Natriuresis Norepinephrine / blood Renin / blood |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1; 0/Endothelin-3; 51-41-2/Norepinephrine; 85637-73-6/Atrial Natriuretic Factor; EC 3.4.23.15/Renin |
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