Document Detail

Daily melatonin intake resets circadian rhythms of a sighted man with non-24-hour sleep-wake syndrome who lacks the nocturnal melatonin rise.
MedLine Citation:
PMID:  9225375     Owner:  NLM     Status:  MEDLINE    
Effects of daily melatonin intake on the circadian rhythms of sleep and wakefulness, rectal temperature and plasma cortisol were examined in a sighted man who had suffered from the non-24-hour sleep-wake syndrome. The subject lacked the nocturnal melatonin rise in plasma, but showed robust circadian rhythms in rectal temperature and plasma cortisol. The sleep-wake rhythm free-ran with a period longer than 24 hours. Daily melatonin intake at 21:00 h concentrated sleep episodes in the nocturnal period (24:00-8:00 h), and increased the length of the episodes. A single oral dose (3 mg) of melatonin increased plasma melatonin levels to about 1300 pg/mL within one hour and remained at pharmacological levels for approximately 6 hours. The trough of rectal temperature and the circadian rise of plasma cortisol were fixed to the early morning. A higher dose of melatonin (6 mg) did not improve the general feature. After the cessation of melatonin intake, the sleep-wake rhythm began to free-run together with the circadian rhythms in rectal temperature and plasma cortisol. It is concluded that daily intake of melatonin at early night time resets the circadian rhythms in a sighted man who lacked the nocturnal melatonin rise and showed free-running circadian rhythms in routine life.
K Nakamura; S Hashimoto; S Honma; K Honma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychiatry and clinical neurosciences     Volume:  51     ISSN:  1323-1316     ISO Abbreviation:  Psychiatry Clin. Neurosci.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-08-27     Completed Date:  1997-08-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9513551     Medline TA:  Psychiatry Clin Neurosci     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  121-7     Citation Subset:  IM    
Department of Physiology, Hokkaido University School of Medicine, Sapporo, Japan.
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MeSH Terms
Administration, Oral
Body Temperature / physiology*
Circadian Rhythm / drug effects*,  physiology
Hydrocortisone / blood*
Longitudinal Studies
Melatonin / administration & dosage*,  metabolism
Sleep Disorders / drug therapy*
Sleep Stages / drug effects*,  physiology
Reg. No./Substance:
50-23-7/Hydrocortisone; 73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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