Document Detail


Daily life blood pressure changes are steeper in hypertensive than in normotensive subjects.
MedLine Citation:
PMID:  12885790     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Target organ damage in hypertensive patients is related to their increased average blood pressure and greater 24-hour blood pressure variability. Whether the rate of blood pressure changes is also greater in hypertension, producing a greater stress on arterial walls, is not known, however. Our study aimed at addressing this issue by computer analysis of 24-hour ambulatory intra-arterial blood pressure recordings in 34 subjects (29 males), 13 normotensive subjects and 21 uncomplicated hypertensive subjects (mean age+/-SD, 40.4+/-11.8 years). The number, slope (mm Hg/s), and length (beats) of systolic blood pressure ramps of 3 or more consecutive beats characterized by a progressive increase (+) or reduction (-) in systolic blood pressure of at least 1 mm Hg per beat were computed for each hour and for the whole 24-hour period. Twenty-four-hour average systolic blood pressure was 112.9+/-2.1 and 159.4+/-5.7 mm Hg in normotensive and hypertensive subjects, respectively. Over the 24 hours, the number and length of systolic blood pressure ramps were similar in both groups, whereas the slope was markedly different (24-hour mean+/-SE slope, 4.80+/-0.30 in normotensives and 6.50+/-0.40 mm Hg/s in hypertensives, P<0.05). Ramp slope was not influenced by age or reflex pulse interval changes, but it was greater for higher ramp initial systolic blood pressure values. Thus, in daily life, hypertensive subjects are characterized by steeper blood pressure changes than normotensives, and this, regardless of the mechanisms, may have clinical implications, because it may be associated with greater traumatic effect on the vessel walls of hypertensive patients.
Authors:
Giuseppe Mancia; Gianfranco Parati; Paolo Castiglioni; Roberto Tordi; Elena Tortorici; Fabio Glavina; Marco Di Rienzo
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2003-07-28
Journal Detail:
Title:  Hypertension     Volume:  42     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-05     Completed Date:  2004-02-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  277-82     Citation Subset:  IM    
Affiliation:
Dipartimento di Medicina Clinica, Prevenzione e Tecnologie Sanitarie, Università di Milano-Bicocca, Milano and Ospedale San Gerardo, Via Donizetti 106, 20052 Monza. giuseppe.mancia@unimib.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / physiology*
Blood Pressure Determination
Circadian Rhythm
Heart Rate / physiology
Humans
Hypertension / physiopathology*
Male
Middle Aged

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