| Daily follow-up of bacterial communities in the human gut reveals stable composition and host-specific patterns of interaction. | |
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MedLine Citation:
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PMID: 22443608 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In the last decade, an extensive effort has been made to characterize the human intestinal microbiota by means of SSU rRNA gene sequence and metagenomic analysis. Relatively few studies have followed intestinal bacterial communities over time to assess their stability in the absence of perturbation. In this study we have monitored the faecal bacteria of three healthy subjects during fifteen consecutive days. The global community structure was analysed through SSU rRNA gene sequencing. In agreement with previous studies, we found that the between-subject variation in community structure was larger than within. The composition was fairly stable throughout, though daily fluctuations were detected for all genera and phylotypes at 97% of sequence identity. While the core shared between subjects was very small, each subject harboured a stable high-abundance core composed of a small number of bacterial groups (9% of the phylotypes accounted for between 74% and 93% of the sequences). This may suggest that studies aimed at linking the microbiota composition with disease risk should be limited to the numerically most dominant phylotypes, as the rest appears transient. Networks of potential interactions between co-occurring genera were also subject-specific, even for the same bacterial genus, which might be reflecting host-specific selective pressures and historic events. © 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved. |
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Authors:
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Ana Durbán; Juan José Abellán; Nuria Jiménez-Hernández; Amparo Latorre; Andrés Moya |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-22 |
Journal Detail:
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Title: FEMS microbiology ecology Volume: - ISSN: 1574-6941 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8901229 Medline TA: FEMS Microbiol Ecol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved. |
Affiliation:
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Joint Research Unit on Genomics and Health, CSISP - Cavanilles Institute of Biodiversity and Evolutionary Biology, University of Valencia, Avenida de Cataluña 21, 46020, Valencia, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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