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Daily dose of clindamycin versus standard divided doses in obstetrical and gynecological infections: A retrospective cohort study.
MedLine Citation:
PMID:  23970615     Owner:  NLM     Status:  Publisher    
Purpose of the studyTo compare the rates of cure of septic abortion and pelvic inflammatory disease using a daily dose of clindamycin with gentamicin versus divided doses.Procedures: DesignIn this retrospective cohort study, electronic records of 661 patients who used clindamycin 1 × , 3 × or 4 ×/day (groups 1, 3 and 4, respectively) between September 2002 and August 2010 were analysed. Major outcomes included rates of cure and failure according to the clinical records. Secondary endpoints were percentage of adverse effects related to medication regimen and the prevalence of positive VDRL and HIV.ConclusionsSimilar conditions were observed in all groups - septic abortion: 167/116/123; pelvic inflammatory disease: 73/95/87 (groups 1, 3 and 4, respectively). No significant difference was found among groups for age or for rate of cure. Rates of cure (cure/total [rate (95%CI)]) in groups 1, 3 and 4 were 236/240 [0.983 (0.957-0.993)], 205/211 [0.971 (0.939-0.986)], 203/210 [0.966 (0.932-0.983)], respectively. Days of use of clindamycin was significantly reduced in group 1, compared to groups 3 and 4 (2.6 ± 1.3 vs. 3.5 ± 2.5 vs. 3.3 ± 1.9-mean ± SD; p < 0.0001-ANOVA), but this may be due to differences in how length of therapy was measured and not to the clinical cure.
Cláudia S Giugno; Alice L Silva; Daniele G Fuhrich; Paola S Rabaioli; Katia G Gonçalves; Nicole C Sartor; Ricardo F Savaris
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-19
Journal Detail:
Title:  International journal of STD & AIDS     Volume:  -     ISSN:  1758-1052     ISO Abbreviation:  Int J STD AIDS     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-8-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007917     Medline TA:  Int J STD AIDS     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Departamento e Serviço de Ginecologia e Obstetrícia, Universidade Federal do Rio Grande do Sul - Hospital de Clínicas de Porto Alegre - Rua Ramiro Barcelos.
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