Document Detail

Daily cost of antimicrobial therapy in patients with Intensive Care Unit-acquired, laboratory-confirmed bloodstream infection.
MedLine Citation:
PMID:  18164599     Owner:  NLM     Status:  MEDLINE    
This study analysed daily antimicrobial costs of Intensive Care Unit (ICU)-acquired, laboratory-confirmed bloodstream infection (BSI) per patient admitted to the ICU of a university hospital, based on prospectively collected data over a 4-year period (2003-2006). Costs were calculated based on the price of the agent(s) initiated on the first day of appropriate treatment and according to: (i) focus of infection; (ii) pathogen; and (iii) antimicrobial agent. The study included 310 adult patients who developed 446 BSI episodes. Mean overall daily antimicrobial cost was euro114.25. Daily antimicrobial cost was most expensive for BSIs with unknown focus (euro137.70), followed by catheter-related (euro122.73), pulmonary (euro112.80), abdominal (euro98.00), wound (euro89.21), urinary (euro87.85) and other inciting focuses (euro81.59). Coagulase-negative staphylococci were the most prevalent pathogens isolated. Treatment of BSIs caused by Candida spp. was the most costly. The daily antimicrobial costs per infected patient with multidrug-resistant BSI was ca. 50% higher compared with those without (euro165.09 vs. euro82.67; P<0.001). Among the total of 852 prescriptions, beta-lactam antibiotics accounted for approximately one-third of the overall daily cost of antimicrobial agents. The antibiotic cost associated with ICU-acquired, laboratory-confirmed BSI is significant and should be reduced by implementing infection control measures and preventive strategies.
Dominique M Vandijck; Mieke Depaemelaere; Sonia O Labeau; Pieter O Depuydt; Lieven Annemans; Franky M Buyle; Sandra Oeyen; Kirsten E Colpaert; Renaat P Peleman; Stijn I Blot; Johan M Decruyenaere
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of antimicrobial agents     Volume:  31     ISSN:  0924-8579     ISO Abbreviation:  Int. J. Antimicrob. Agents     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-08     Completed Date:  2008-06-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111860     Medline TA:  Int J Antimicrob Agents     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  161-5     Citation Subset:  IM    
Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, Ghent, Belgium.
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MeSH Terms
Anti-Infective Agents / administration & dosage*,  economics*,  therapeutic use
Bacteremia / drug therapy,  economics*
Bacteria / classification,  drug effects
Drug Resistance, Multiple
Hospital Costs / statistics & numerical data*
Hospitals, University / economics,  utilization*
Infection Control / economics*
Intensive Care Units / economics*,  statistics & numerical data
Prospective Studies
Reg. No./Substance:
0/Anti-Infective Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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