Document Detail


Daily treadmill exercise attenuates cocaine cue-induced reinstatement and cocaine induced locomotor response but increases cocaine-primed reinstatement.
MedLine Citation:
PMID:  23103403     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exercise affects neuroplasticity and neurotransmission including dopamine (DA), which modulates drug-taking behavior. Previous research in rodents has shown that exercise may attenuate the rewarding effects of drugs of abuse. The present study examined the effects of high and low exercise on cocaine responses in male Wistar rats that had been trained to self-administer and were compared to a group of sedentary rats. High exercise rats (HE) ran daily on a treadmill for 2h and low exercise (LE) ran daily for 1h. After 6 weeks of this exercise regimen, rats were tested over 2 days for reinstatement (day 1: cue-induced reinstatement; day 2: cocaine-primed reinstatement). During cue-induced reinstatement, the sedentary rats showed the expected increase in active lever responses when compared to maintenance, whereas these increased responses were inhibited in the exercised rats (HE and LE). During cocaine-primed reinstatement, however, there was a significant increase in active lever presses when compared to maintenance only in the HE group. This data suggests that chronic exercise during abstinence attenuates the cue-induced reinstatement seen in the sedentary rats by 26% (LE) and 21% (HE). In contrast, only the high exercise rats exhibited sensitized cocaine-seeking behavior (active lever presses) following cocaine-primed reinstatement. Finally, while sedentary rats increased locomotor activity during cocaine-primed reinstatement over that seen with cocaine during maintenance, this was not observed in the exercised rats, suggesting that exercise may interfere with the sensitized locomotor response during cocaine reinstatement.
Authors:
Panayotis K Thanos; Joshua Stamos; Lisa S Robison; Gary Heyman; Andrew Tucci; Gene-Jack Wang; John K Robinson; Brenda J Anderson; Nora D Volkow
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-26
Journal Detail:
Title:  Behavioural brain research     Volume:  239     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2012-12-18     Completed Date:  2013-06-04     Revised Date:  2014-02-18    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  8-14     Citation Subset:  IM    
Copyright Information:
Published by Elsevier B.V.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cocaine / administration & dosage,  adverse effects,  pharmacology*
Cocaine-Related Disorders / prevention & control*,  therapy*
Conditioning, Operant / drug effects
Cues
Disease Models, Animal
Exercise Therapy / methods,  psychology*
Extinction, Psychological / drug effects*
Male
Motor Activity / drug effects*
Rats
Rats, Wistar
Recurrence / prevention & control
Self Administration
Time Factors
Grant Support
ID/Acronym/Agency:
AA 11034/AA/NIAAA NIH HHS; AA07574/AA/NIAAA NIH HHS; AA07611/AA/NIAAA NIH HHS; Z99 AA999999/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
I5Y540LHVR/Cocaine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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