Document Detail


Daily diaries vs retrospective questionnaires to assess asthma control and therapeutic responses in asthma clinical trials: is participant burden worth the effort?
MedLine Citation:
PMID:  23287844     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Presently, there is insufficient information to compare the value of daily diaries vs retrospective questionnaires for assessing symptoms in relationship to asthma control in clinical trials. Daily symptom diaries are often burdensome to gather, incomplete, susceptible to fabrication, and of questionable reliability. There is also concern that retrospective symptom questionnaires may be subject to poor recall and may be insensitive.
METHODS: To compare these two methods of assessing symptoms reporting, we analyzed data collected during the Best Add-on Therapy Giving Effective Responses (BADGER) trial. During the trial, asthma control in 182 children aged 6 to 17 years was assessed in two ways: (1) by asthma control days (ACDs) determined by manually recorded daily diary symptom and rescue medication use scores and (2) by monthly retrospective report of symptoms embedded within the age-appropriate version of the Asthma Control Test (ACT). Correlations between ACDs and ACT scores were analyzed, and the sensitivity of each method for measuring asthma control and determining the differential response among the three BADGER treatments was evaluated.
RESULTS: Although validated using a 4-week recall period, ACT correlated better with daily diary information from the last 2 weeks of the 4-week recall (r = 0.46) than from the first 2 weeks (r = 0.34). In addition, clinically significant differential treatment responses were detected using ACDs but not ACT scores .
CONCLUSIONS: The results of this study indicate that daily diaries used to determine ACDs can be a more sensitive tool than ACT for assessing differential treatment responses with respect to asthma control.
Authors:
Adesua Y Okupa; Christine A Sorkness; David T Mauger; Daniel J Jackson; Robert F Lemanske
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Chest     Volume:  143     ISSN:  1931-3543     ISO Abbreviation:  Chest     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-02     Completed Date:  2013-07-08     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  993-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Anti-Asthmatic Agents / therapeutic use*
Asthma / drug therapy*
Child
Female
Humans
Male
Medical Records*
Mental Recall
Questionnaires*
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Treatment Outcome
Grant Support
ID/Acronym/Agency:
HL064287/HL/NHLBI NIH HHS; HL064288/HL/NHLBI NIH HHS; HL064295/HL/NHLBI NIH HHS; HL064305/HL/NHLBI NIH HHS; HL064307,/HL/NHLBI NIH HHS; HL064313/HL/NHLBI NIH HHS; M01-RR00036/RR/NCRR NIH HHS; M01-RR00051/RR/NCRR NIH HHS; M01-RR03186/RR/NCRR NIH HHS; T32AI007635/AI/NIAID NIH HHS; UL1 RR024992/RR/NCRR NIH HHS; UL1 TR000427/TR/NCATS NIH HHS; UL1-RR024992/RR/NCRR NIH HHS; UL1-RR025011/RR/NCRR NIH HHS; UL1-RR025780/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Asthmatic Agents
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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