| Daily alignment results of in-room computed tomography-guided stereotactic body radiation therapy for lung cancer. | |
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MedLine Citation:
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PMID: 20399032 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine the extent of interfractional setup errors and day-to-day organ motion errors by assessing daily bone alignment results and changes in soft tissue tumor position during hypofractionated, in-room computed tomography (CT)-guided stereotactic body radiation therapy (SBRT) of lung cancer. METHODS AND MATERIALS: Daily alignment results during SBRT were analyzed for 117 tumors in 112 patients. Patients received 40-50 Gy of SBRT in four to five fractions using an integrated CT-LINAC system. The free-breathing CT scans acquired during treatment setup were retrospectively realigned to match with each of the bony references and the gross tumor volume (GTV) defined on the reference CT by rigid-body registration, and the daily deviations were calculated. RESULTS: The mean magnitude (± SD) three-dimensional shift from the initial skin marks to the final bone-aligned positions was 9.4 ± 5.7 mm. The mean daily GTV deviation from the bone position was 0.1 ± 3.8 mm in the anterior-posterior direction, -0.01 ± 4.2 mm in the superior-inferior direction, and 0.2 ± 2.5 mm in the lateral direction. A clinically noteworthy trend (net change >5 mm in any direction) in GTV position relative to the bone was observed in 23 cases (20%). CONCLUSIONS: Soft tissue target position can change significantly beyond the motion envelope defined in the original internal target volume in four-dimensional CT-based treatment planning for SBRT of lung cancer. Additional margin should be considered for adequate coverage of interfractional changes. |
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Authors:
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Hitoshi Ikushima; Peter Balter; Ritsuko Komaki; Sandeep Hunjun; M Kara Bucci; Zhongxing Liao; Mary F McAleer; Zhiqian H Yu; Yongbin Zhang; Joe Y Chang; Lei Dong |
Publication Detail:
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Type: Journal Article Date: 2010-04-14 |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 79 ISSN: 1879-355X ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-03 Completed Date: 2011-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
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Languages: eng Pagination: 473-80 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bone and Bones
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radiography Carcinoma, Non-Small-Cell Lung / pathology, radiography, surgery* Dose Fractionation Female Humans Lung Neoplasms / pathology, radiography, surgery* Male Movement* Radiosurgery / methods* Radiotherapy, Computer-Assisted / methods Reproducibility of Results Retrospective Studies Time Factors Tomography, X-Ray Computed / methods* Tumor Burden |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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