| Daidzein-metabolising phenotypes in relation to serum lipids and uric acid in adults in Guangzhou, China. | |
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MedLine Citation:
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PMID: 20205965 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies have suggested that daidzein's metabolites, equol and O-desmethylangolensin (O-DMA), rather than daidzein itself may contribute to the beneficial effects of soya foods in the prevention of CVD. The present study aims to assess the proportion of equol and O-DMA producers, and to compare differences in anthropometric factors, serum lipids, glucose and uric acid between producers and non-producers in Chinese adults aged 20-69 years. For the present cross-sectional study, 202 subjects (100 women and 102 men) were recruited. Twenty-four-hour urinary daidzein and its metabolites were determined in these subjects while on their usual diet and again after a 3-d isoflavone challenge. Fasting serum lipids, glucose and uric acid were examined on their usual diet. Three days of 24 h dietary recalls were used to assess dietary intakes. Of the 202 subjects, 27 (13.4 %) and 27 (13.4 %) excreted equol and O-DMA on their usual diet, and 101 (50 %) and 94 (46.5 %) produced equol and O-DMA after a load of 80 mg/d isoflavones. Equol producers showed lower serum uric acid ( - 10.2 %, P = 0.001), TAG ( - 29.5 %, P = 0.007) and waist:hip ratio ( - 2.6 %, P = 0.032), and tended to have higher HDL cholesterol (6.3 %, P = 0.069) compared with equol non-producers. There were no significant differences in serum lipids, glucose and uric acid between O-DMA producers and non-producers. In conclusion, equol phenotypes might influence cardiovascular risk. |
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Authors:
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Kaiping Guo; Bo Zhang; Chaogang Chen; Shigeto Uchiyama; Tomomi Ueno; Yuming Chen; Yixiang Su |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-08 |
Journal Detail:
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Title: The British journal of nutrition Volume: 104 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-07-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 118-24 Citation Subset: IM |
Affiliation:
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Faculty of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cardiovascular Diseases / prevention & control China Cholesterol, HDL / blood Cross-Sectional Studies Diet Records Female Humans Isoflavones / administration & dosage, metabolism*, urine* Lipids / blood* Male Middle Aged Phenotype Phytoestrogens Risk Factors Triglycerides / blood Uric Acid / blood* Waist-Hip Ratio* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Isoflavones; 0/Lipids; 0/Phytoestrogens; 0/Triglycerides; 21255-69-6/O-desmethylangolensin; 486-66-8/daidzein; 531-95-3/equol; 69-93-2/Uric Acid |
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