| Daclizumab use in patients with pediatric multiple sclerosis. | |
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MedLine Citation:
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PMID: 22232346 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Daclizumab, a humanized monoclonal antibody specific for the interleukin 2 receptor α chain, reduces clinical and magnetic resonance imaging disease activity in patients with adult-onset multiple sclerosis (MS) as monotherapy or add-on therapy with interferon. OBJECTIVE: To report the use of daclizumab in pediatric-onset MS. DESIGN: Case series. SETTING: Two comprehensive pediatric MS centers. Patients Seven patients with pediatric-onset MS with clinical and magnetic resonance imaging disease activity despite first-line disease-modifying therapy. Intervention Intravenous daclizumab, 1 mg/kg monthly. MAIN OUTCOME MEASURES: Annualized relapse rates, Expanded Disability Status Scale scores, contrast-enhancing lesions, and adverse effects. RESULTS: Treatment with daclizumab, primarily combined with interferon, was associated with reductions in annualized relapse rates and contrast-enhancing lesions and with reduction or stabilization of Expanded Disability Status Scale scores in each patient. However, 4 patients had relapses and new contrast-enhancing lesions during daclizumab treatment. No significant adverse effects occurred. CONCLUSION: Daclizumab may be a safe and at least partially effective treatment option for patients with pediatric-onset MS with disease activity despite first-line disease-modifying therapy. |
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Authors:
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Mark P Gorman; Jan-Mendelt Tillema; Annika M Ciliax; Charles R G Guttmann; Tanuja Chitnis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of neurology Volume: 69 ISSN: 1538-3687 ISO Abbreviation: Arch. Neurol. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 78-81 Citation Subset: AIM; IM |
Affiliation:
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Partners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital, ACC-708, 55 Fruit St, Boston, MA 02114. tchitnis@partners.org. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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