| Dabigatran etexilate for stroke prevention in patients with atrial fibrillation: Resolving uncertainties in routine practice. | |
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MedLine Citation:
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PMID: 22318514 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Dabigatran etexilate is a new oral anticoagulant recently approved in Europe for the prevention of stroke or systemic embolism in adult patients with non-valvular atrial fibrillation (AF) and at least one risk factor for stroke. With a fast onset of action and a predictable anticoagulant effect obviating the need for coagulation monitoring, dabigatran etexilate offers practical advantages over vitamin K antagonists in clinical practice. However, clinicians may have questions about practical aspects of dabigatran etexilate use including monitoring anticoagulant efficacy, interruption for surgical or invasive procedures and management of bleeding. This review article aims to address these concerns and provide guidance on the use of dabigatran etexilate in special situations, such as acute coronary syndromes and cardiac revascularisation. In addition, cut-off values for different coagulation assay results associated with an increased risk of bleeding are given. |
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Authors:
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M V Huisman; G Y H Lip; H-C Diener; M Brueckmann; J van Ryn; A Clemens |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-08 |
Journal Detail:
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Title: Thrombosis and haemostasis Volume: 107 ISSN: 0340-6245 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Menno V. Huisman, Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, Netherlands, Tel.: +31 752 62085, Fax: +31 71 5248140, E-mail: M.V.Huisman@lumc.nl. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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