Document Detail

DU-176b, an oral, direct Factor Xa antagonist.
MedLine Citation:
PMID:  17729190     Owner:  NLM     Status:  MEDLINE    
Daiichi Sankyo Inc (formerly Daiichi Seiyaku Co Ltd) is developing DU-176b, a direct, orally active Factor Xa inhibitor, as an anticoagulant for the potential treatment of cardiovascular indications, including venous and arterial thrombosis. By January 2005, phase II studies had begun in the US and Europe, and by March 2006, phase II studies had begun in Japan. Phase II trials for the prevention of thromboembolism were ongoing in mid 2007.
Elaine Hylek
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in investigational drugs (London, England : 2000)     Volume:  8     ISSN:  1472-4472     ISO Abbreviation:  Curr Opin Investig Drugs     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-30     Completed Date:  2007-10-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100965718     Medline TA:  Curr Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  778-83     Citation Subset:  IM    
Boston University Medical Center, Department of Medicine, 91 East Concord Street, Suite 200, Boston, MA 02118, USA.
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MeSH Terms
Administration, Oral
Anticoagulants / administration & dosage,  adverse effects,  pharmacokinetics,  therapeutic use*,  toxicity
Factor Xa / antagonists & inhibitors*,  metabolism
Patents as Topic
Structure-Activity Relationship
Thromboembolism / drug therapy*,  metabolism
Treatment Outcome
Venous Thrombosis / drug therapy*,  metabolism
Reg. No./Substance:
0/Anticoagulants; EC Xa

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