| DU-176b, an oral, direct Factor Xa antagonist. | |
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MedLine Citation:
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PMID: 17729190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Daiichi Sankyo Inc (formerly Daiichi Seiyaku Co Ltd) is developing DU-176b, a direct, orally active Factor Xa inhibitor, as an anticoagulant for the potential treatment of cardiovascular indications, including venous and arterial thrombosis. By January 2005, phase II studies had begun in the US and Europe, and by March 2006, phase II studies had begun in Japan. Phase II trials for the prevention of thromboembolism were ongoing in mid 2007. |
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Authors:
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Elaine Hylek |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in investigational drugs (London, England : 2000) Volume: 8 ISSN: 1472-4472 ISO Abbreviation: Curr Opin Investig Drugs Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-30 Completed Date: 2007-10-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100965718 Medline TA: Curr Opin Investig Drugs Country: England |
Other Details:
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Languages: eng Pagination: 778-83 Citation Subset: IM |
Affiliation:
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Boston University Medical Center, Department of Medicine, 91 East Concord Street, Suite 200, Boston, MA 02118, USA. ehylek@bu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Anticoagulants / administration & dosage, adverse effects, pharmacokinetics, therapeutic use*, toxicity Factor Xa / antagonists & inhibitors*, metabolism Humans Patents as Topic Structure-Activity Relationship Thromboembolism / drug therapy*, metabolism Treatment Outcome Venous Thrombosis / drug therapy*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; EC 3.4.21.6/Factor Xa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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