| DTI and MR Volumetry of Hippocampus-PC/PCC Circuit: In Search of Early Micro- and Macrostructural Signs of Alzheimers's Disease. | |
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MedLine Citation:
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PMID: 21773026 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Hippocampal damage, by DTI or MR volumetry, and PET hypoperfusion of precuneus/posterior cingulate cortex (PC/PCC) were proposed as biomarkers of conversion from preclinical (MCI) to clinical stage of Alzheimer's disease (AD). This study evaluated structural damage, by DTI and MR volumetry, of hippocampi and tracts connecting hippocampus to PC/PCC (hipp-PC/PCC) in 10 AD, 10 MCI, and 18 healthy controls (CTRL). Normalized volumes, mean diffusivity (MD), and fractional anisotropy (FA) were obtained for grey matter (GM), white matter (WM), hippocampi, PC/PCC, and hipp-PC/PCC tracts. In hippocampi and hipp-PC/PCC tracts, decreased volumes and increased MD were found in AD versus CTRL (P < .001). The same results with lower significance (P < .05) were found in MCI versus CTRL. Verbal memory correlated (P < .05) in AD with left hippocampal and hipp-PC/PCC tract MD, and in MCI with FA of total WM. Both DTI and MR volumetry of hippocampi and hipp-PC/PCC tracts detect early signs of AD in MCI patients. |
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Authors:
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F Palesi; P Vitali; P Chiarati; G Castellazzi; E Caverzasi; A Pichiecchio; E Colli-Tibaldi; F D'Amore; I D'Errico; E Sinforiani; S Bastianello |
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Publication Detail:
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Type: Journal Article Date: 2011-06-12 |
Journal Detail:
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Title: Neurology research international Volume: 2012 ISSN: 2090-1860 ISO Abbreviation: Neurol Res Int Publication Date: 2012 |
Date Detail:
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Created Date: 2011-07-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101543314 Medline TA: Neurol Res Int Country: United States |
Other Details:
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Languages: eng Pagination: 517876 Citation Subset: - |
Affiliation:
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Neuroradiology Unit, IRCCS Foundation National Neurological Institute C. Mondino, 27100 Pavia, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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