Document Detail


The DRiP hypothesis decennial: support, controversy, refinement and extension.
MedLine Citation:
PMID:  16815756     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 1996, to explain the rapid presentation of viral proteins to CD8+ T cells, it was proposed that peptides presented by MHC class I molecules derive from defective ribosomal products (DRiPs), presumed to be polypeptides arising from in-frame translation that fail to achieve native structure owing to inevitable imperfections in transcription, translation, post-translational modifications or protein folding. Here, we consider findings that address the DRiP hypothesis, and extend the hypothesis by proposing that cells possess specialized machinery, possibly in the form of "immunoribosomes", to couple protein synthesis to antigen presentation.
Authors:
Jonathan W Yewdell; Christopher V Nicchitta
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2006-07-11
Journal Detail:
Title:  Trends in immunology     Volume:  27     ISSN:  1471-4906     ISO Abbreviation:  Trends Immunol.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-18     Completed Date:  2006-11-22     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  100966032     Medline TA:  Trends Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  368-73     Citation Subset:  IM    
Affiliation:
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0440, USA. JYEWDELL@niaid.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigen Presentation
Histocompatibility Antigens Class I / genetics,  immunology*
Humans
Models, Biological
Ribosomal Proteins / genetics,  immunology*
Ribosomes / genetics*,  immunology*,  metabolism
T-Lymphocytes / immunology
Grant Support
ID/Acronym/Agency:
DK 053058/DK/NIDDK NIH HHS; DK 47897/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Histocompatibility Antigens Class I; 0/Ribosomal Proteins

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