| DRESS-syndrome on sulfasalazine and naproxen treatment for juvenile idiopathic arthritis and reactivation of human herpevirus 6 in an 11-year-old Caucasian boy. | |
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MedLine Citation:
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PMID: 20831538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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DRESS-syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a severe drug-induced hypersensitivity syndrome characterized by diffuse maculopapular rash, lymphadenopathy, multivisceral involvement, eosinophilia and atypical lymphocytes with a mortality rate of 10-40% (Seminars in Cutaneous Medicine and Surgery, 1, 250). It is described in adults treated with aromatic antiepileptics and less frequently with sulphonamides, and non-steroidal anti-inflammatory drugs (Clinics in Dermatology, 23, 171; Pediatrics, 108, 485). We report on an 11-year-old Caucasian boy hospitalized with a skin eruption, lymphadenopathy, acute hepatitis, renal tubular involvement, haematological abnormalities and human-herpevirus-6 reactivation, treated with sulfasalazine and naproxen for juvenile idiopathic arthritis (JIA). This is the first report in children with rheumatic disease and highlights the possibility of sulfasalazine and naproxen-induced-DRESS-syndrome in children with JIA. |
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Authors:
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E Piñana; S H Lei; R Merino; M Melgosa; R De La Vega; E Gonzales-Obeso; E Ramírez; A Borobia; A Carcas |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of clinical pharmacy and therapeutics Volume: 35 ISSN: 1365-2710 ISO Abbreviation: J Clin Pharm Ther Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2010-12-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8704308 Medline TA: J Clin Pharm Ther Country: England |
Other Details:
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Languages: eng Pagination: 365-70 Citation Subset: IM |
Affiliation:
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Clinical Pharmacology Department, Hospital Universitario La Paz, School of Medicine, Universidad Autónoma de Madrid, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents, Non-Steroidal
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adverse effects,
therapeutic use Arthritis, Juvenile Rheumatoid / drug therapy Child Drug Eruptions / etiology* Drug Therapy, Combination Herpesvirus 6, Human / isolation & purification Humans Male Naproxen / adverse effects*, therapeutic use Roseolovirus Infections / virology Sulfasalazine / adverse effects*, therapeutic use Syndrome Virus Activation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 22204-53-1/Naproxen; 599-79-1/Sulfasalazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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