| DRD4 genotype moderates the impact of parental problems on unresolved loss or trauma. | |
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MedLine Citation:
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PMID: 21506030 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the current study we tested whether the dopamine receptor D4 (DRD4) genotype moderates the association of experienced parental problems during childhood (e.g., parental depression, marital discord) with unresolved loss or trauma during the Adult Attachment Interview. To test the specificity of this moderation the role of the serotonin transporter gene promoter (5-HTTLPR) was also examined. Subjects were 124 adopted adults (mean age 39 years). Participants with the DRD4-7 repeat (7R) allele who experienced parental problems had the highest scores for unresolved loss or trauma whereas participants with DRD4-7R who did not experience parental problems showed the lowest ratings. Among participants without DRD4-7R, the parental problems during childhood did not make a difference. 5-HTTLPR did not moderate the relation between parental problems and unresolved loss or trauma. Our study shows heightened susceptibility to environmental influences for carriers of the DRD4-7R allele, and suggests that the interplay between specific dopamine-related genes and family contexts leads to more or less successful coping with adverse childhood experiences. |
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Authors:
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Marian J Bakermans-Kranenburg; Marinus H van IJzendoorn; Kristin Caspers; Robert Philibert |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Attachment & human development Volume: 13 ISSN: 1469-2988 ISO Abbreviation: Attach Hum Dev Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-20 Completed Date: 2011-09-19 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 100901315 Medline TA: Attach Hum Dev Country: England |
Other Details:
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Languages: eng Pagination: 253-69 Citation Subset: IM |
Affiliation:
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Centre for Child and Family Studies, Leiden University, the Netherlands. bakermans@fsw.leidenuniv.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anxiety, Separation / genetics Female Genotype* Humans Male Middle Aged Parenting / psychology* Parents / psychology* Receptors, Dopamine D4 / genetics* Serotonin Plasma Membrane Transport Proteins / genetics* Stress Disorders, Traumatic / genetics* United States |
| Grant Support | |
ID/Acronym/Agency:
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R01 DA005821-18/DA/NIDA NIH HHS; R01 DA015789/DA/NIDA NIH HHS; R01 DA015789-05/DA/NIDA NIH HHS; R01 DA05821/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DRD4 protein, human; 0/SLC6A4 protein, human; 0/Serotonin Plasma Membrane Transport Proteins; 137750-34-6/Receptors, Dopamine D4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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