Document Detail


DRD4 exon III polymorphism and response to risperidone in Israeli adolescents with schizophrenia: a pilot pharmacogenetic study.
MedLine Citation:
PMID:  12729944     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined the possible association between the polymorphism in the dopamine receptor DRD4 gene and response to risperidone among 24 Israeli Jewish adolescent inpatients with first-episode schizophrenia. Response was categorically determined by a change of >40% on the Brief Psychiatric Rating Scale (BPRS). No significant association was found between the DRD4 genotype and clinical response, although carriers of <7 repeat alleles demonstrated higher response rate (10/20 vs. 0/4, P=0.11). Studies in larger groups of adolescent schizophrenia patients are warranted to clarify the possible association between DRD4 exon III repeat alleles and the response to risperidone.
Authors:
Gil Zalsman; Amos Frisch; Shaul Lev-Ran; Andrés Martin; Elena Michaelovsky; Daniela Bensason; Doron Gothelf; Eitan Nahshoni; Samuel Tyano; Abraham Weizman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology     Volume:  13     ISSN:  0924-977X     ISO Abbreviation:  Eur Neuropsychopharmacol     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-05     Completed Date:  2003-07-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9111390     Medline TA:  Eur Neuropsychopharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  183-5     Citation Subset:  IM    
Affiliation:
Adolescent Inpatient Department, Geha Mental Health Center, Rabin Medical Center, Petach Tikva 49100, Israel. zalsman@post.tau.ac.il
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Alleles
Antipsychotic Agents / therapeutic use*
DNA / genetics
Exons / genetics*
Female
Gene Frequency
Humans
Israel
Male
Pharmacogenetics
Pilot Projects
Polymorphism, Genetic / genetics*
Psychiatric Status Rating Scales
Receptors, Dopamine D2 / genetics*
Receptors, Dopamine D4
Risperidone / therapeutic use*
Schizophrenia / drug therapy*,  genetics*
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 0/DRD4 protein, human; 0/Receptors, Dopamine D2; 106266-06-2/Risperidone; 137750-34-6/Receptors, Dopamine D4; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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