Document Detail


The DRD4 VNTR polymorphism moderates craving after alcohol consumption.
MedLine Citation:
PMID:  11950104     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent research has suggested that alterations in mesolimbic dopamine neurotransmission are central to the development and expression of craving for alcohol. Because the D4 dopamine receptor gene, variable numbers of tandem repeats (DRD4 VNTR) polymorphism putatively expresses functional differences in dopamine receptors, the present study tested whether this polymorphism influences the effects of a priming dose of alcohol on craving. Participants consumed 3 alcoholic drinks or 3 control drinks and completed measures of craving after each drink. Participants who were homozygous or heterozygous for the 7 (or longer) repeat allele were classified as DRD4 L, whereas the other participants were classified as DRD4 S. Results suggested that DRD4 L participants demonstrated significantly higher craving after consumption of alcohol as compared with the control beverage.
Authors:
Kent E Hutchison; John McGeary; Andrew Smolen; Angela Bryan; Robert M Swift
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Health psychology : official journal of the Division of Health Psychology, American Psychological Association     Volume:  21     ISSN:  0278-6133     ISO Abbreviation:  Health Psychol     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-04-12     Completed Date:  2002-10-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8211523     Medline TA:  Health Psychol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  139-46     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of Colorado at Boulder, 80309-0345, USA. kenth@psych.colorado.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Drinking / genetics*
Alcoholism / genetics*
Analysis of Variance
Behavior, Addictive / genetics
Ethanol / pharmacology*
Female
Humans
Male
Minisatellite Repeats
Polymorphism, Genetic*
Receptors, Dopamine D2 / genetics*
Receptors, Dopamine D4
Grant Support
ID/Acronym/Agency:
R01AA11473/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/DRD4 protein, human; 0/Receptors, Dopamine D2; 137750-34-6/Receptors, Dopamine D4; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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