| DRD4 7-repeat polymorphism moderates the association between maternal unresolved loss or trauma and infant disorganization. | |
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MedLine Citation:
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PMID: 17178609 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies have related attachment disorganization in children to either dopamine D4 receptor polymorphisms or maternal unresolved loss or trauma and frightening or anomalous parenting. In this study it was examined whether the interaction between genetic (DRD4 7-repeat and -521 C/T) and environmental risk factors (maternal unresolved loss/trauma and maternal frightening behavior) was associated with infant disorganization. A moderating role of the DRD4 gene was found. Maternal unresolved loss or trauma was associated with infant disorganization, but only in the presence of the DRD4 7-repeat polymorphism. The increase in risk for disorganization in children with the 7-repeat allele exposed to maternal unresolved loss/trauma compared to children without these combined risks was 18.8 fold. Similar moderating effects were not found for maternal frightening behavior. Our findings indicate that children are differentially susceptible to unresolved loss or trauma dependent on the presence of the 7-repeat DRD4 allele. |
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Authors:
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Marinus H Van Ijzendoorn; Marian J Bakermans-Kranenburg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Attachment & human development Volume: 8 ISSN: 1461-6734 ISO Abbreviation: Attach Hum Dev Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-20 Completed Date: 2007-03-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901315 Medline TA: Attach Hum Dev Country: England |
Other Details:
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Languages: eng Pagination: 291-307 Citation Subset: IM |
Affiliation:
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Centre for Child and Family Studies, Leiden University, The Netherlands. vanijzen@fsw.leidenuniv.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Anxiety, Separation / genetics Bereavement* Caspases, Initiator Fear Female Genotype Humans Infant Infant Behavior / physiology, psychology* Male Minisatellite Repeats Mother-Child Relations* Mothers / psychology* Object Attachment* Parenting / psychology* Polymorphism, Genetic* Receptors, Dopamine D4 / genetics* Stress Disorders, Traumatic / psychology* |
| Chemical | |
Reg. No./Substance:
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0/DRD4 protein, human; 137750-34-6/Receptors, Dopamine D4; EC 3.4.22.-/CASP4 protein, human; EC 3.4.22.-/Caspases, Initiator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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