| DPPH radical scavenging and xanthine oxidase inhibitory activity of Terminalia macroptera leaves. | |
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MedLine Citation:
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PMID: 21922915 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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From a methanol extract of the leaves of the Malian medicinal tree Terminalia macroptera, cis-polyisoprene (1), chebulic acid trimethyl ester (2), methyl gallate (3), shikimic acid (4), corilagin (5), rutin (6), narcissin (7), chebulagic acid (8) and chebulinic acid (9), were isolated. Cispolyisoprene (1) was the major non-polar constituent. The novel compound 2 showed high radical scavenging activity (IC50 4.7 microg/mL), but was inactive as xanthine oxidase inhibitor. The major substituent of the crude extract, substance 5, showed a high radical scavenger effect (IC50 2.7 microg/mL) and weak xanthine oxidase inhibition (IC50 ca 105 microg/mL). The antioxidant and radical scavenging effects of some of the substances identified in this study may to some extent explain the medical use of this tree in West Africa. |
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Authors:
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Anh Thu Pham; Karl Egil Malterud; Berit Smestad Paulsen; Drissa Diallo; Helle Wangensteen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Natural product communications Volume: 6 ISSN: 1934-578X ISO Abbreviation: Nat Prod Commun Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-09-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101477873 Medline TA: Nat Prod Commun Country: United States |
Other Details:
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Languages: eng Pagination: 1125-8 Citation Subset: IM |
Affiliation:
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Section of Pharmacognosy, Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, N-0316 Oslo, Norway. a.t.pham@farmasi.uio.no |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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