| DP(2) receptor antagonists in development. | |
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MedLine Citation:
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PMID: 20615077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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IMPORTANCE OF THE FIELD: In asthmatic lung, allergen challenge leads to the production of large quantities of (prostaglandin D(2)) PGD(2) which both contracts human airway tissue and stimulates an inflammatory response. The identification of PGD(2) as the cognate ligand for a second specific receptor, the DP(2) receptor and the limited inhibition of its pro-inflammatory effects by TP or DP(1) receptor antagonists provide the stimulus to identify, and characterize, selective DP(2) antagonists. This has led to considerable interest in the development of such agents, stimulated by promising initial clinical data. AREAS COVERED IN THIS REVIEW: The 10 DP(2) antagonists reported to be in clinical development are considered in as much detail as possible from available information. Reported preclinical efforts are also considered and contrasted to more advanced agents. WHAT THE READER WILL GAIN: A comprehensive overview of the state of the art in the development of DP(2) antagonists for the treatment of asthma, and knowledge of the companies which are currently actively seeking to develop such agents. TAKE HOME MESSAGE: Considerable progress has been made in the development of selective DP(2) antagonists and initial indications are that they could prove a useful new option in the treatment of asthma. More comprehensive clinical results that will shortly become available will further clarify their therapeutic potential and also indicate the possibility of their use in the treatment of chronic obstructive pulmonary disease. |
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Authors:
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Peter Norman |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert opinion on investigational drugs Volume: 19 ISSN: 1744-7658 ISO Abbreviation: Expert Opin Investig Drugs Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-15 Completed Date: 2010-10-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9434197 Medline TA: Expert Opin Investig Drugs Country: England |
Other Details:
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Languages: eng Pagination: 947-61 Citation Subset: IM |
Affiliation:
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Norman Consulting, Burnham, Bucks, UK. peter.norman2@btinternet.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Asthmatic Agents / chemistry, pharmacology*, therapeutic use Anti-Inflammatory Agents, Non-Steroidal / chemistry, pharmacology*, therapeutic use Asthma / drug therapy* Clinical Trials as Topic Drug Design* Female Humans Male Molecular Structure Prostaglandin D2 / metabolism* Receptors, Immunologic / antagonists & inhibitors*, metabolism Receptors, Prostaglandin / antagonists & inhibitors*, metabolism Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Anti-Asthmatic Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Receptors, Immunologic; 0/Receptors, Prostaglandin; 0/prostaglandin D2 receptor; 41598-07-6/Prostaglandin D2 |
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