Document Detail

The DOTS strategy for treatment of paediatric pulmonary tuberculosis in South Delhi, India.
MedLine Citation:
PMID:  18173881     Owner:  NLM     Status:  MEDLINE    
SETTING: Paediatric Pulmonology Department, TB Institute, New Delhi, India. OBJECTIVE: To evaluate the outcome of the DOTS strategy for paediatric pulmonary tuberculosis (TB). DESIGN: Retrospective analysis of 1098 children. RESULTS: The mean age of the children included in the study was 11.2 years, with more females (61.7%) than males (38.3%). In the 0-5, 6-10 and 11-14 year age groups, the percentage of patients was respectively 18.3%, 26.6% and 55.1%. Patients were registered as new cases (87.7%), relapses (1.9%), failures (1.0%), defaulters (5.0%), transferred in (0.9%) and others (3.5%). Of the total number of cases, 414 were smear-positive and 404 smear-negative, while sputum status was not known for 280 patients. Sputum positivity increased with age. Category I, II and III regimens were started by respectively 50.6%, 10.5% and 38.9% patients. The cure rate was 92.4% (302/327) for new and 92% (80/87) for retreatment cases (chi(2)(1) = 0.02, P = 0.901), but the treatment completion rate was significantly higher for new cases (97%, 636/656) than retreatment cases (53.6%, 15/28) (chi(2)(1) = 100.8, P < 0.001). The overall success rate was 95.4% and 82.6% for new and retreatment cases, respectively (chi(2)(1) = 30.35, P < 0.001). Overall, the rates for default, failure and death in the study were respectively 3%, 1.9% and 1%. CONCLUSION: DOTS appears to be a highly efficacious treatment strategy.
S Sharma; R Sarin; U K Khalid; N Singla; P P Sharma; D Behera
Publication Detail:
Type:  Evaluation Studies; Journal Article; Multicenter Study    
Journal Detail:
Title:  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease     Volume:  12     ISSN:  1027-3719     ISO Abbreviation:  Int. J. Tuberc. Lung Dis.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-04     Completed Date:  2008-03-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706389     Medline TA:  Int J Tuberc Lung Dis     Country:  France    
Other Details:
Languages:  eng     Pagination:  74-80     Citation Subset:  IM    
Department of Paediatric Pulmonology, Lala Ram Sarup (LRS) Institute of Tuberculosis & Respiratory Diseases, New Delhi, India.
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MeSH Terms
Age Distribution
Antitubercular Agents / therapeutic use*
Child, Preschool
Directly Observed Therapy* / statistics & numerical data
India / epidemiology
Infant, Newborn
Mycobacterium tuberculosis / isolation & purification*
National Health Programs* / statistics & numerical data
Outcome and Process Assessment (Health Care)* / statistics & numerical data
Patient Compliance
Program Evaluation
Retrospective Studies
Sputum / microbiology
Treatment Failure
Treatment Outcome
Tuberculosis, Pulmonary / drug therapy*,  microbiology,  mortality
Reg. No./Substance:
0/Antitubercular Agents

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