Document Detail


DOTATOC: a powerful new tool for receptor-mediated radionuclide therapy.
MedLine Citation:
PMID:  9211767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study presents the first successful use of a peptidic vector, DOTATOC, labelled with the beta-emitting radioisotope yttrium-90, for the treatment of a patient with somatostatin receptor-positive abdominal metastases of a neuroendocrine carcinoma of unknown localization. Tumour response and symptomatic relief were achieved. In addition, the new substance DOTATOC was labelled with the diagnostic chemical analogue indium-111 and studied in three patients with histopathologically verified neuroendocrine abdominal tumours for its diagnostic sensitivity and compared with the commercially available OctreoScan. In all patients the kidney-to-tumour uptake ratio (in counts per pixel) was on average 1. 9-fold lower with 111In-DOTATOC than with OctreoScan. DOTATOC could be a potential new diagnostic and therapeutic agent in the management of neuroendocrine tumours.
Authors:
A Otte; E Jermann; M Behe; M Goetze; H C Bucher; H W Roser; A Heppeler; J Mueller-Brand; H R Maecke
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of nuclear medicine     Volume:  24     ISSN:  0340-6997     ISO Abbreviation:  Eur J Nucl Med     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-08     Completed Date:  1997-09-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7606882     Medline TA:  Eur J Nucl Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  792-5     Citation Subset:  IM    
Affiliation:
Institute of Nuclear Medicine, University Hospital, School of Medicine, Basel, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Abdominal Neoplasms / metabolism,  radionuclide imaging*,  radiotherapy*
Adult
Humans
Indium Radioisotopes / diagnostic use*
Male
Middle Aged
Neuroendocrine Tumors / metabolism,  radionuclide imaging*,  radiotherapy*
Octreotide / analogs & derivatives*,  diagnostic use,  therapeutic use
Pentetic Acid / analogs & derivatives,  diagnostic use
Radiopharmaceuticals / diagnostic use,  therapeutic use*
Receptors, Somatostatin / analysis*
Sensitivity and Specificity
Yttrium Radioisotopes / therapeutic use*
Chemical
Reg. No./Substance:
0/(DOTA(0)-Phe(1)-Tyr(3))octreotide; 0/Indium Radioisotopes; 0/Radiopharmaceuticals; 0/Receptors, Somatostatin; 0/Yttrium Radioisotopes; 142694-57-3/SDZ 215-811; 67-43-6/Pentetic Acid; 83150-76-9/Octreotide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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