| DNP in MRI: An in-bore approach at 1.5T. | |
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MedLine Citation:
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PMID: 22248644 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We have used liquid state ("Overhauser") Dynamic Nuclear Polarization (DNP) to significantly enhance the signal to noise ratio (SNR) of Magnetic Resonance Imaging (MRI). For the first time this was achieved by hyperpolarizing directly in the MRI-scanner field of 1.5T in continuous flow mode and immediately delivering the hyperpolarized substance to the imaging site to ensure maximum contrast between hyperpolarized sample and sample at thermal polarization. We achieve a maximum absolute signal enhancement factor of 98; while the hyperpolarized sample is transported at a flow rate of up to 30ml/h yielding an average flow speed up to 470mm/s over a distance of approximately 80mm. A spatial imaging resolution of 100μm with a signal to noise ratio of 25 was achieved on the flowing sample. Application to MRI contrast enhancement or microfluidic imaging can be envisaged immediately. |
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Authors:
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Jan G Krummenacker; Vasyl P Denysenkov; Maxim Terekhov; Laura M Schreiber; Thomas F Prisner |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-30 |
Journal Detail:
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Title: Journal of magnetic resonance (San Diego, Calif. : 1997) Volume: - ISSN: 1096-0856 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9707935 Medline TA: J Magn Reson Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Institute of Physical and Theoretical Chemistry and Center of Biomolecular Magnetic Resonance, Goethe University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt, Germany; Section of Medical Physics, Department of Diagnostic and Interventional Radiology, Johannes Gutenberg University Medical Center, Langenbeckstraße 1, 55131 Mainz, Germany. |
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