| DNAzymes for sensing, nanobiotechnology and logic gate applications. | |
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MedLine Citation:
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PMID: 18497928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Catalytic nucleic acids (DNAzymes or ribozymes) are selected by the systematic evolution of ligands by exponential enrichment process (SELEX). The catalytic functions of DNAzymes or ribozymes allow their use as amplifying labels for the development of optical or electronic sensors. The use of catalytic nucleic acids for amplified biosensing was accomplished by designing aptamer-DNAzyme conjugates that combine recognition units and amplifying readout units as in integrated biosensing materials. Alternatively, "DNA machines" that activate enzyme cascades and yield DNAzymes were tailored, and the systems led to the ultrasensitive detection of DNA. DNAzymes are also used as active components for constructing nanostructures such as aggregated nanoparticles and for the activation of logic gate operations that perform computing. |
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Authors:
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Itamar Willner; Bella Shlyahovsky; Maya Zayats; Bilha Willner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-04-24 |
Journal Detail:
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Title: Chemical Society reviews Volume: 37 ISSN: 0306-0012 ISO Abbreviation: Chem Soc Rev Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-23 Completed Date: 2008-08-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0335405 Medline TA: Chem Soc Rev Country: England |
Other Details:
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Languages: eng Pagination: 1153-65 Citation Subset: IM |
Affiliation:
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Institute of Chemistry, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biosensing Techniques* Catalysis Computers, Molecular DNA / analysis* DNA, Catalytic / chemistry* Nanotechnology* SELEX Aptamer Technique |
| Chemical | |
Reg. No./Substance:
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0/DNA, Catalytic; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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