| DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study. | |
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MedLine Citation:
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PMID: 17956875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: C-reactive protein represents the classical acute-phase protein produced in the liver in response to inflammatory stimuli. This study evaluated the association of gene polymorphisms with differences in C-reactive protein concentrations and assessed its intra-individual variability as a marker of individual response. METHODS AND RESULTS: One thousand and three myocardial infarction (MI) survivors were recruited in six European cities, and C-reactive protein concentrations were measured repeatedly during a 6-month period. We investigated 114 polymorphisms in 13 genes, all involved in the innate inflammatory pathway. We found two polymorphisms within the C-reactive protein (CRP) gene rs1800947 and rs1205, of which the minor alleles were strongly associated with lower levels of C-reactive protein (P < 10(-6)). A haplotype, identified by those two polymorphisms, was associated with the lowest C-reactive protein concentrations (P < 10(-6)). Additionally, the minor alleles of several variants were significantly associated with greater individual variability of C-reactive protein concentrations (P < 10(-3)). CONCLUSION: The present study investigated the association of polymorphisms with inter- and intra-individual variability of C-reactive protein levels. Two minor alleles of C-reactive protein variants were associated with lower C-reactive protein concentrations. Regarding intra-individual variability, we observed associations with the minor alleles of several variants in selected candidate genes, including the CRP gene itself. |
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Authors:
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Melanie Kolz; Wolfgang Koenig; Martina Müller; Mariarita Andreani; Sonja Greven; Thomas Illig; Natalie Khuseyinova; Demosthenes Panagiotakos; Göran Pershagen; Veikko Salomaa; Jordi Sunyer; Annette Peters; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2007-10-22 |
Journal Detail:
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Title: European heart journal Volume: 29 ISSN: 1522-9645 ISO Abbreviation: Eur. Heart J. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-15 Completed Date: 2008-07-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 1250-8 Citation Subset: IM |
Affiliation:
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GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged C-Reactive Protein / genetics, metabolism* DNA / genetics, metabolism* Female Genotype Humans Male Middle Aged Myocardial Infarction / blood* Polymorphism, Single Nucleotide |
| Chemical | |
Reg. No./Substance:
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9007-41-4/C-Reactive Protein; 9007-49-2/DNA |
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