Document Detail


DNA vaccines for transplantation.
MedLine Citation:
PMID:  20373844     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
IMPORTANCE OF THE FIELD: DNA vaccination for transplantation has been less investigated compared with DNA vaccines for infectious disease, cancer and pathological autoimmunity. However, the emerging role of transplant-induced autoimmunity in allograft rejection may lead to the development of new DNA vaccination approaches where peripheral delivery of an antigen shared by recipient and allograft could be used to prevent rejection of a given organ for large numbers of individuals. In addition, apoptosis-inducing DNA vaccines could further minimize the need to identify specific donor antigens for induction of tolerance by generating apoptotic cells carrying donor or recipient antigens depending on site of vaccine delivery.
AREA COVERED IN THIS REVIEW: The review covers DNA vaccination approaches that have been taken to prolong allograft survival in different animal model systems and their possible immune mechanisms and speculates on the future role of DNA vaccines for transplantation.
WHAT THE READER WILL GAIN: The review gives insight into how new DNA vaccination strategies might be developed to take into account recent development in allotransplantation.
TAKE HOME MESSAGE: DNA vaccination could reduce the need for systemic immunosuppressants and be applied to prevention of chronic rejection, which remains a major barrier to successful allotransplantation.
Authors:
Alice F Li; Alan Escher
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Expert opinion on biological therapy     Volume:  10     ISSN:  1744-7682     ISO Abbreviation:  Expert Opin Biol Ther     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-07     Completed Date:  2010-08-12     Revised Date:  2011-08-25    
Medline Journal Info:
Nlm Unique ID:  101125414     Medline TA:  Expert Opin Biol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  903-15     Citation Subset:  IM    
Affiliation:
Department of Basic Sciences, Loma Linda University, School of Medicine and Medical Center, Loma Linda, California 92354, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoimmunity
Graft Rejection / immunology
Humans
Immune Tolerance
Tissue Donors
Transplantation Immunology*
Vaccines, DNA / therapeutic use*
Chemical
Reg. No./Substance:
0/Vaccines, DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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