| DNA testing for hypertrophic cardiomyopathy: a cost-effectiveness model. | |
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MedLine Citation:
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PMID: 20299350 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Aims To explore the cost-effectiveness of alternative methods of screening family members for hypertrophic cardiomyopathy (HCM), the most common monogenic cardiac disorder and the most frequent cause of sudden cardiac death (SCD) in young people. Methods and results Economic decision model comparing cascade screening by genetic, as opposed to clinical methods. The incremental cost per life year saved was 14,397 euro for the cascade genetic compared with the cascade clinical approach. Genetic diagnostic strategies are more likely to be cost-effective than clinical tests alone. The costs for cascade molecular genetic testing were slightly higher than clinical testing in the short run, but this was largely because the genetic approach is more effective and identifies more individuals at risk. Conclusion The use of molecular genetic information in the diagnosis and management of HCM is a cost-effective approach to the primary prevention of SCD in these patients. |
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Authors:
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Sarah Wordsworth; José Leal; Edward Blair; Rosa Legood; Kate Thomson; Anneke Seller; Jenny Taylor; Hugh Watkins |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-18 |
Journal Detail:
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Title: European heart journal Volume: 31 ISSN: 1522-9645 ISO Abbreviation: Eur. Heart J. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 926-35 Citation Subset: IM |
Affiliation:
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Health Economics Research Centre, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK. sarah.wordsworth@dphpc.ox.ac.uk |
Export Citation:
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| Grant Support | |
ID/Acronym/Agency:
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//Department of Health |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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