| DNA strand breakage by peroxidase-activated mitoxantrone. | |
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MedLine Citation:
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PMID: 1676068 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Spectroscopic evidence demonstrate that the alkylaminoanthraquinone mitoxantrone is a substrate for horseradish peroxidase in the presence of hydrogen peroxide and that the result of this interaction is the formation of an air-stable mitoxantrone-derived free radical. The mitoxantrone-derived free radicals or their further oxidation products appear to extensively cross-link with plasmid DNA by a reaction that is mitoxantrone concentration-dependent. Oxidative activation of mitoxantrone to a DNA-damaging species may contribute to the mechanism of action of this antitumour agent. |
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Authors:
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G R Fisher; L H Patterson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 43 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 1991 Jan |
Date Detail:
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Created Date: 1991-07-31 Completed Date: 1991-07-31 Revised Date: 2006-05-01 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 65-8 Citation Subset: IM |
Affiliation:
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Department of Pharmacy, Leicester Polytechnic, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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DNA Damage DNA, Single-Stranded / drug effects*, metabolism Drug Interactions Electron Spin Resonance Spectroscopy Free Radicals Horseradish Peroxidase / pharmacology* Hydrogen Peroxide / pharmacology* Mitoxantrone / pharmacology* Plasmids / drug effects |
| Chemical | |
Reg. No./Substance:
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0/DNA, Single-Stranded; 0/Free Radicals; 65271-80-9/Mitoxantrone; 7722-84-1/Hydrogen Peroxide; EC 1.11.1.-/Horseradish Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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