| DNA single strand breaks induced by low levels of occupational exposure to styrene: the gap between standards and reality. | |
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MedLine Citation:
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PMID: 11934013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Styrene is a known mutagen and suspected carcinogen, used in the reinforced plastic industry. This study aims to identify the occurrence of DNA single strand breaks (SSBs) in workers exposed to styrene levels far below the recommended standards. We compared 26 exposed workers with 26 control subjects and found a significant increase in the incidence of DNA-SSBs in the exposed individuals. The levels of the biological indices of exposure (urinary mandelic and phenyl glyoxylic acids) were less than 25% of the recommended limits. Reduction of the threshold limit values/time-weighted-average (TLV-TWA) applied is strongly recommended. |
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Authors:
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Magdy Y Shamy; Hazem H Osman; Kamal M Kandeel; Nehad M Abdel-Moneim; Said Khalid F El |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer Volume: 21 ISSN: 0731-8898 ISO Abbreviation: J. Environ. Pathol. Toxicol. Oncol. Publication Date: 2002 |
Date Detail:
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Created Date: 2002-04-05 Completed Date: 2002-04-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8501420 Medline TA: J Environ Pathol Toxicol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 57-61 Citation Subset: IM |
Affiliation:
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High Institute of Public Health, Occupational Health Department, Alexandria University, Egypt. magdyshamy@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / analysis DNA Damage* DNA, Single-Stranded Dose-Response Relationship, Drug Ethylene Glycols / urine Humans Male Mandelic Acids / urine Middle Aged Occupational Exposure* Reference Values Styrene / administration & dosage, toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/DNA, Single-Stranded; 0/Ethylene Glycols; 0/Mandelic Acids; 100-42-5/Styrene; 90-64-2/mandelic acid; 93-56-1/styrene glycol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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