Document Detail

DNA secondary structures: stability and function of G-quadruplex structures.
MedLine Citation:
PMID:  23032257     Owner:  NLM     Status:  MEDLINE    
In addition to the canonical double helix, DNA can fold into various other inter- and intramolecular secondary structures. Although many such structures were long thought to be in vitro artefacts, bioinformatics demonstrates that DNA sequences capable of forming these structures are conserved throughout evolution, suggesting the existence of non-B-form DNA in vivo. In addition, genes whose products promote formation or resolution of these structures are found in diverse organisms, and a growing body of work suggests that the resolution of DNA secondary structures is critical for genome integrity. This Review focuses on emerging evidence relating to the characteristics of G-quadruplex structures and the possible influence of such structures on genomic stability and cellular processes, such as transcription.
Matthew L Bochman; Katrin Paeschke; Virginia A Zakian
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-10-03
Journal Detail:
Title:  Nature reviews. Genetics     Volume:  13     ISSN:  1471-0064     ISO Abbreviation:  Nat. Rev. Genet.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-18     Completed Date:  2013-01-04     Revised Date:  2013-07-31    
Medline Journal Info:
Nlm Unique ID:  100962779     Medline TA:  Nat Rev Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  770-80     Citation Subset:  IM    
Department of Molecular Biology, Princeton University, 101 Lewis Thomas Laboratory, Washington Rd., Princeton, New Jersey 08544, USA.
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MeSH Terms
Base Sequence
Chromosome Mapping
DNA / chemistry*,  genetics
DNA Replication
Gene Expression Regulation
Genomic Instability
Models, Genetic
Models, Molecular*
Grant Support
Reg. No./Substance:

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