Document Detail

DNA replication timing of the human beta-globin domain is controlled by histone modification at the origin.
MedLine Citation:
PMID:  18443145     Owner:  NLM     Status:  MEDLINE    
The human beta-globin genes constitute a large chromosomal domain that is developmentally regulated. In nonerythroid cells, these genes replicate late in S phase, while in erythroid cells, replication is early. The replication origin is packaged with acetylated histones in erythroid cells, yet is associated with deacetylated histones in nonerythroid cells. Recruitment of histone acetylases to this origin brings about a transcription-independent shift to early replication in lymphocytes. In contrast, tethering of a histone deacetylase in erythroblasts causes a shift to late replication. These results suggest that histone modification at the origin serves as a binary switch for controlling replication timing.
Alon Goren; Amalia Tabib; Merav Hecht; Howard Cedar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-28
Journal Detail:
Title:  Genes & development     Volume:  22     ISSN:  0890-9369     ISO Abbreviation:  Genes Dev.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-16     Completed Date:  2008-07-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1319-24     Citation Subset:  IM    
Department of Cellular Biochemistry and Human Genetics, Hebrew University Medical School, Ein Kerem, Jerusalem 91120, Israel.
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MeSH Terms
DNA Replication Timing*
Globins / genetics*
Histone Acetyltransferases / metabolism*
Histones / metabolism*
Mice, Transgenic
Protein Processing, Post-Translational / physiology
Protein Structure, Tertiary / genetics
Replication Origin*
Reg. No./Substance:
0/Histones; 9004-22-2/Globins; EC Acetyltransferases

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