Document Detail


DNA replication timing of the human beta-globin domain is controlled by histone modification at the origin.
MedLine Citation:
PMID:  18443145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human beta-globin genes constitute a large chromosomal domain that is developmentally regulated. In nonerythroid cells, these genes replicate late in S phase, while in erythroid cells, replication is early. The replication origin is packaged with acetylated histones in erythroid cells, yet is associated with deacetylated histones in nonerythroid cells. Recruitment of histone acetylases to this origin brings about a transcription-independent shift to early replication in lymphocytes. In contrast, tethering of a histone deacetylase in erythroblasts causes a shift to late replication. These results suggest that histone modification at the origin serves as a binary switch for controlling replication timing.
Authors:
Alon Goren; Amalia Tabib; Merav Hecht; Howard Cedar
Related Documents :
4033145 - Morphometric study of the interphase nucleus in some radiosensitive and radioresistant ...
3394945 - Exclusion chromatography with controlled-pore glass beads to isolate chlorella chromati...
7645975 - Discordant effects of butyrate analogues on erythroleukemia cell proliferation, differe...
16522665 - Alterations of histone modifications and transgene silencing by nickel chloride.
8764065 - The outcome of poliovirus infections in k562 cells is cytolytic rather than persistent ...
18641365 - Cells that produce deleterious autoreactive antibodies are vulnerable to suicide.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-28
Journal Detail:
Title:  Genes & development     Volume:  22     ISSN:  0890-9369     ISO Abbreviation:  Genes Dev.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-16     Completed Date:  2008-07-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1319-24     Citation Subset:  IM    
Affiliation:
Department of Cellular Biochemistry and Human Genetics, Hebrew University Medical School, Ein Kerem, Jerusalem 91120, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetylation
Animals
DNA Replication Timing*
Globins / genetics*
Histone Acetyltransferases / metabolism*
Histones / metabolism*
Humans
Mice
Mice, Transgenic
Protein Processing, Post-Translational / physiology
Protein Structure, Tertiary / genetics
Replication Origin*
Chemical
Reg. No./Substance:
0/Histones; 9004-22-2/Globins; EC 2.3.1.48/Histone Acetyltransferases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Religion, risk, and medical decision making at the end of life.
Next Document:  Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by M...