| DNA replication checkpoint promotes G1-S transcription by inactivating the MBF repressor Nrm1. | |
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MedLine Citation:
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PMID: 18682565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cell cycle transcriptional program imposes order on events of the cell-cycle and is a target for signals that regulate cell-cycle progression, including checkpoints required to maintain genome integrity. Neither the mechanism nor functional significance of checkpoint regulation of the cell-cycle transcription program are established. We show that Nrm1, an MBF-specific transcriptional repressor acting at the transition from G(1) to S phase of the cell cycle, is at the nexus between the cell cycle transcriptional program and the DNA replication checkpoint in fission yeast. Phosphorylation of Nrm1 by the Cds1 (Chk2) checkpoint protein kinase, which is activated in response to DNA replication stress, promotes its dissociation from the MBF transcription factor. This leads to the expression of genes encoding components that function in DNA replication and repair pathways important for cell survival in response to arrested DNA replication. |
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Authors:
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R A M de Bruin; T I Kalashnikova; A Aslanian; J Wohlschlegel; C Chahwan; J R Yates; P Russell; C Wittenberg |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-08-05 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 105 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-13 Completed Date: 2008-09-16 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 11230-5 Citation Subset: IM |
Affiliation:
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Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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DNA Repair
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physiology DNA Replication / physiology* DNA, Fungal / genetics, metabolism* G1 Phase / physiology* Genome, Fungal / physiology Phosphorylation Protein-Serine-Threonine Kinases / genetics, metabolism Repressor Proteins / genetics, metabolism* S Phase / physiology* Schizosaccharomyces / genetics, metabolism* Schizosaccharomyces pombe Proteins / genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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CA77325/CA/NCI NIH HHS; GM059441/GM/NIGMS NIH HHS; GM59447/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA, Fungal; 0/Nrm1 protein, S pombe; 0/Repressor Proteins; 0/Schizosaccharomyces pombe Proteins; EC 2.7.1.11/checkpoint kinase 2; EC 2.7.11.1/Protein-Serine-Threonine Kinases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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