Document Detail

DNA repair in the context of chromatin.
MedLine Citation:
PMID:  15753656     Owner:  NLM     Status:  MEDLINE    
Modulation of chromatin is essential to nuclear processes that utilize DNA, such as transcription, replication, and repair. For example, transcription is assisted by histone post-translational modifications, as well as chromatin-remodeling complexes, which alter the structure of chromatin. Furthermore, recent advancements in the fields of DNA repair and chromatin reveal that both histone modifications and chromatin-remodeling complexes are essential for the repair of DNA lesions. In particular, chromatin-modifying complexes, such as the INO80 chromatin-remodeling complex and the Tip60 histone acetyltransferase complex, associate with the DNA damage-induced phosphorylated H2AX, which is often referred to as gamma-H2AX. In S. cerevisiae, the association of INO80 with gamma-H2AX is required for the recruitment of INO80 to sites of DNA double-strand breaks. Additionally, in Drosophila, Tip60 exchanges gamma-H2AX for unmodified H2A in regions of DNA damage. This report reviews recent studies that emphasize the intimate relationship between evolutionarily-conserved chromatin-modifying complexes and histone post-translational modifications in the repair of DNA damage.
Ashby J Morrison; Xuetong Shen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2005-04-21
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  4     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-05-23     Completed Date:  2006-05-05     Revised Date:  2011-09-28    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  568-71     Citation Subset:  IM    
Department of Carcinogenesis, Science Park Research Division, University of Texas, MD Anderson Cancer Center, Smithville, Texas 78957, USA.
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MeSH Terms
Cell Cycle
Chromatin / chemistry*
Chromosomes / chemistry
DNA / chemistry*
DNA Damage
DNA Repair*
Histone Acetyltransferases / chemistry
Histones / chemistry
Nucleosomes / chemistry
Protein Processing, Post-Translational
Transcription, Genetic
Reg. No./Substance:
0/Chromatin; 0/Histones; 0/Nucleosomes; 9007-49-2/DNA; EC 2.3.1.-/KAT5 protein, human; EC Acetyltransferases

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