Document Detail


DNA repair by the MRN complex: break it to make it.
MedLine Citation:
PMID:  18854148     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Genomic instability in ataxia telangiectasia-like disorder and Nijmegen breakage syndrome is due to disruption of the Mre11-Rad50-Nbs1 complex. Buis et al. (2008) and Williams et al. (2008) now reveal the importance of the nuclease activity of Mre11 for mammalian genome maintenance and present a molecular view of its active site.
Authors:
Roland Kanaar; Claire Wyman
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Cell     Volume:  135     ISSN:  1097-4172     ISO Abbreviation:  Cell     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-15     Completed Date:  2008-10-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14-6     Citation Subset:  IM    
Affiliation:
Department of Cell Biology and Genetics, Cancer Genomics Center, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
DNA Breaks, Double-Stranded*
DNA Repair*
DNA Repair Enzymes / chemistry,  genetics,  metabolism*
Mice
Multienzyme Complexes / chemistry,  genetics,  metabolism
Chemical
Reg. No./Substance:
0/Multienzyme Complexes; EC 6.5.1.-/DNA Repair Enzymes
Comments/Corrections
Comment On:
Cell. 2008 Oct 3;135(1):85-96   [PMID:  18854157 ]
Cell. 2008 Oct 3;135(1):97-109   [PMID:  18854158 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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