Document Detail


DNA polymorphisms of apolipoprotein B and angiotensin I-converting enzyme genes and relationships with lipid levels in Italian patients with vascular dementia or Alzheimer's disease.
MedLine Citation:
PMID:  9681639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The distribution of three DNA polymorphisms (XbaI, EcoRI, and I/D) of the apolipoprotein B (APOB) gene, and of the I/D polymorphism of the angiotensin I-converting enzyme (ACE) gene was investigated in 53 patients with vascular dementia, in 80 patients with late-onset sporadic Alzheimer's disease, and in 153 age-matched control subjects. Furthermore, plasma total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides were measured in the three groups and the involvement of the genetic variation at APOB locus on lipid levels was determined. Major findings of this work are (1) no genotype or allele of the polymorphisms examined here seemed to be associated with vascular dementia or with Alzheimer's disease, (2) total cholesterol and LDL cholesterol levels were lower in Alzheimer's disease patients than in vascular dementia patients and in elderly controls, and (3) the dementia patients with APOB EcoRI R+R- genotype had higher total cholesterol and LDL cholesterol levels than R+R+ homozygotes.
Authors:
R Scacchi; L De Bernardini; E Mantuano; T Vilardo; L M Donini; M Ruggeri; A T Gemma; R Pascone; R M Corbo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  9     ISSN:  1420-8008     ISO Abbreviation:  Dement Geriatr Cogn Disord     Publication Date:    1998 Jul-Aug
Date Detail:
Created Date:  1998-10-22     Completed Date:  1998-10-22     Revised Date:  2008-03-24    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  186-90     Citation Subset:  IM    
Affiliation:
CNR Center of Evolutionary Genetics, Department of Genetics and Molecular Biology, University La Sapienza, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alleles
Alzheimer Disease / blood,  genetics*
Apolipoproteins B / genetics*
Case-Control Studies
Cholesterol / blood
Cholesterol, HDL / blood
DNA / genetics
Dementia, Vascular / blood,  genetics*
Female
Gene Dosage
Genotype
Humans
Italy
Lipids / blood*
Male
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic / genetics*
Chemical
Reg. No./Substance:
0/Apolipoproteins B; 0/Cholesterol, HDL; 0/Lipids; 57-88-5/Cholesterol; 9007-49-2/DNA; EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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