Document Detail


DNA polymorphism in the uncoupling protein 1 (UCP1) gene has no effect on obesity related phenotypes in the Swedish Obese Subjects cohorts.
MedLine Citation:
PMID:  9665669     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the relationships between the A-G point mutation at position -3826 bp in the 5' flanking domain of the uncoupling protein 1 (UCP1 A-3826G) and some obesity phenotypes in the Swedish Obese Subjects (SOS) cohorts of obese and non-obese men and women. Previous studies have supported the hypothesis of an association between the UCP1 A-3826G polymorphism and body weight regulation in humans.
DESIGN: Case-control study comparing obese subjects from the SOS registry and a sample of the Swedish general population (body mass index (BMI) <27 kg/m2) with respect to genotype and allele frequencies of the UCP1 A-3826G polymorphism.
SUBJECTS: A total of 985 Swedish subjects including 674 obese (310 Male; 364 Female) and 311 non-obese subjects (54 Male; 257 Female) from the SOS cohorts.
MEASUREMENTS: DNA was extracted from total blood and genotyped by PCR-RFLP. Obesity-related phenotypes include weight history for SOS obese cohort and current weight, BMI, waist circumference and waist to hip ratio (WHR) for obese and normal weight subjects.
RESULTS: No significant difference in the allelic frequencies between obese and non-obese subjects (0.25 vs 0.24; P = 0.67). In both genders, current weight, BMI, waist circumference, WHR and weight gain over time (either measures of maximal weight ever achieved minus weight at 20 y or current weight minus weight at 20 y) were similar in carriers and non-carriers of the UCP1 A-3826G mutation (P>0.05). Similar results were obtained when the three genotypes were compared.
CONCLUSIONS: In contrast to what was found in other populations, the UCP1 A-3826G sequence variation is not associated with obesity-related phenotypes and weight gain over time in subjects from the SOS cohorts.
Authors:
J Gagnon; F Lago; Y C Chagnon; L Pérusse; I Näslund; L Lissner; L Sjöström; C Bouchard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity     Volume:  22     ISSN:  -     ISO Abbreviation:  Int. J. Obes. Relat. Metab. Disord.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-07-31     Completed Date:  1998-07-31     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9313169     Medline TA:  Int J Obes Relat Metab Disord     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  500-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Body Constitution
Body Mass Index
Carrier Proteins / genetics*
Cohort Studies
DNA / blood
Female
Genotype
Humans
Ion Channels
Male
Membrane Proteins / genetics*
Middle Aged
Mitochondrial Proteins
Obesity / genetics*
Phenotype*
Point Mutation
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length*
Sweden
Weight Gain
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Ion Channels; 0/Membrane Proteins; 0/Mitochondrial Proteins; 0/mitochondrial uncoupling protein; 9007-49-2/DNA
Comments/Corrections
Comment In:
Int J Obes Relat Metab Disord. 1998 Dec;22(12):1244-5   [PMID:  9877262 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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