Document Detail


DNA ploidy, expression of p53 protein and metastatic behaviour of gastric carcinoma.
MedLine Citation:
PMID:  9387398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
DNA ploidy of 57 gastric carcinomas with metastases (12 liver, 1 adrenal, 4 ovary and 48 lymph node) were measured by flow cytometry. DNA anueploidy was significantly related to liver metastases: 9 out of 12 gastric carcinomas with liver metastases were anueploid (75%) as compared to 13 out of 45 (28.8%) of cases without liver metastases (P < 0.01); the one gastric carcinoma with adrenal metastasis was also anueploid. DNA ploidy was not related to ovarian or lymph node metastases. Another interesting finding was that all of 3 gastric carcinomas with liver metastases which showed a diploid DNA pattern, expressed p53 protein, while all of 3 carcinomas with liver metastases but no p53 protein expression were anueploid. The expression of p53 protein was not related to ovarian metastases. The results suggested that an anueploid DNA pattern and the expression of p53 protein are both objective markers valuable in predicting high risk potential of metastases to the liver, and that the combined detection of these markers can be a most useful method in the follow-up of patients with gastric carcinoma in detecting those at high risk of developing metastases following surgical resection. Also the poorer prognosis of patients with gastric carcinoma showing an anueploid DNA pattern may be related to the development of distant organ metastases through the blood vascular system. Furthermore, the clone of gastric carcinoma cells which accumulate p53 protein or show an anueploid DNA pattern may have a causative role in the development of liver (& adrenal) metastases.
Authors:
Y Xin; F Zhao; D Wu; Y Wang; L Xu; B Curran; M Leader; K Henry
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences     Volume:  11     ISSN:  1001-9294     ISO Abbreviation:  Chin. Med. Sci. J.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-12-31     Completed Date:  1997-12-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9112559     Medline TA:  Chin Med Sci J     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  147-51     Citation Subset:  IM    
Affiliation:
Cancer Institute of China Medical University, Shenyang.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / genetics*,  pathology
Aneuploidy
DNA, Neoplasm / genetics*
Humans
Liver Neoplasms / genetics,  secondary*
Lymphatic Metastasis
Stomach Neoplasms / genetics*,  pathology
Tumor Suppressor Protein p53 / biosynthesis*
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 0/Tumor Suppressor Protein p53

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