Document Detail


DNA ploidy as a prognostic factor in early esophageal carcinoma.
MedLine Citation:
PMID:  8325588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell nuclear DNA content was cytophotometrically determined in biopsy specimens obtained from thirty-five patients with superficial esophageal carcinoma. The relationship between the DNA distribution pattern and histopathological features, prognosis and postoperative survival time was then investigated. Patients with a low ploidy pattern had a more favorable postoperative course, with 62% attaining a 5-year survival rate, than those with high ploidy, of whom 34% attained a 5-year survival rate (p < 0.01). The recurrence rate was higher for the high ploidy pattern (64.3%) than for the low ploidy pattern (35.3%). Moreover, the rate of recurrence within 2 years was 50% in high ploidy, which was higher than the 5.9% rate in the case of low ploidy (p < 0.05). Although there was no clearly established relationship between the DNA distribution pattern and clinicopathological features, a multivariate analysis revealed that the DNA distribution pattern was one of the independent and significant prognostic factors of superficial esophageal carcinoma. These results thus suggest the usefulness of a preoperative DNA analysis of biopsy specimens in predicting the prognosis and determining perioperative therapeutic strategy for both superficial esophageal carcinoma and for advanced cases.
Authors:
M Ikebe; K Kitamura; K Baba; M Morita; S Tsutsui; K Sugimachi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  40     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-08-12     Completed Date:  1993-08-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  232-5     Citation Subset:  IM    
Affiliation:
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Biopsy
Carcinoma, Squamous Cell / mortality,  pathology*,  surgery
DNA, Neoplasm / analysis*
Esophageal Neoplasms / mortality,  pathology*,  surgery
Esophagus / pathology
Female
Follow-Up Studies
Humans
Lymph Nodes / pathology
Lymphatic Metastasis
Male
Middle Aged
Neoplastic Cells, Circulating
Ploidies*
Precancerous Conditions / mortality,  pathology*,  surgery
Survival Rate
Chemical
Reg. No./Substance:
0/DNA, Neoplasm

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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