| DNA nanostructure serum stability: greater than the sum of its parts. | |
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MedLine Citation:
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PMID: 23287884 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Simple chemical modifications to oligonucleotide ends with hexaethylene glycol and hexanediol are shown to significantly increase nuclease resistance under serum conditions. The modified oligonucleotides were used to construct DNA prismatic cages in a single step and in quantitative yield. These cages further stabilize their strands towards nucleases, with lifetimes of 62 hours in serum. The cages contain a large number of single-stranded regions for functionalization, illustrating their versatility for biological applications. |
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Authors:
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Justin W Conway; Christopher K McLaughlin; Katherine J Castor; Hanadi Sleiman |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-4 |
Journal Detail:
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Title: Chemical communications (Cambridge, England) Volume: - ISSN: 1364-548X ISO Abbreviation: Chem. Commun. (Camb.) Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610838 Medline TA: Chem Commun (Camb) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Chemistry, 801 Sherbrooke St. West, Montreal, QC, CanadaH3A0B8. hanadi.sleiman@mcgill.ca. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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