Document Detail

DNA nanostructure serum stability: greater than the sum of its parts.
MedLine Citation:
PMID:  23287884     Owner:  NLM     Status:  Publisher    
Simple chemical modifications to oligonucleotide ends with hexaethylene glycol and hexanediol are shown to significantly increase nuclease resistance under serum conditions. The modified oligonucleotides were used to construct DNA prismatic cages in a single step and in quantitative yield. These cages further stabilize their strands towards nucleases, with lifetimes of 62 hours in serum. The cages contain a large number of single-stranded regions for functionalization, illustrating their versatility for biological applications.
Justin W Conway; Christopher K McLaughlin; Katherine J Castor; Hanadi Sleiman
Related Documents :
6814534 - Are pyrimidine dimers tolerated during dna replication of uv-irradiated parvovirus minu...
9750104 - Photorepair mutants of arabidopsis.
24297254 - Structure and dna-binding properties of the bacillus subtilis spoiiie dna translocase r...
24103574 - Label-free electrochemical biosensor using home-made 10-methyl-3-nitro-acridone as indi...
15080664 - 5'-tethered stilbene derivatives as fidelity- and affinity-enhancing modulators of dna ...
8346174 - Image analysis versus flow cytometry for dna ploidy quantitation of solid tumors: a com...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-4
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  -     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Chemistry, 801 Sherbrooke St. West, Montreal, QC, CanadaH3A0B8.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  "Well, I think there is great variation...": a qualitative study of oncologists' experiences and vie...
Next Document:  Revealing dynamic processes of materials in liquids using liquid cell transmission electron microsco...