| DNA microarray analysis of transcriptional responses of rats housed on solid and grid cage flooring. | |
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MedLine Citation:
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PMID: 22293427 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We performed DNA microarray analysis on the white blood cells (WBCs) of rats housed on solid and grid cage flooring. The expression levels of 50 genes were found to increase more than 2-fold in the WBCs on grid cage flooring, including many genes encoding proteins involved in inflammatory or immune responses. It is therefore suggested that the health and welfare of laboratory rats is likely to be improved by housing rats on solid floors. |
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Authors:
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Masayuki Uehara; Ayako Nishio; Satoshi Inoue; Kiyoshi Matsumoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of toxicological sciences Volume: 37 ISSN: 1880-3989 ISO Abbreviation: J Toxicol Sci Publication Date: 2012 |
Date Detail:
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Created Date: 2012-02-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805798 Medline TA: J Toxicol Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 219-22 Citation Subset: IM |
Affiliation:
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Division of Laboratory Animal Research, Research Center for Human and Environmental Sciences, Shinshu University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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