| The DNA-methylation state regulates virulence and stress response of Salmonella | |
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MedLine Citation:
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PMID: 18722983 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The DNA methylation is a post-replicative event that provides secondary information to that formed by DNA. Addition of this information involves DAM methyltransferase, which methylates DNA on specific sites (5'-GATC-3'). This modification of DNA may play a role in regulating various processes in eukaryote or prokaryote cells. It was well understood that deoxyadenosine methyltransferase (DAM) methylates the adenine of the GATC sequence. Following DNA replication, however, DNA is transiently hemimethylated, and the new strand is then methylated by DAM. In Escherichia coli, removing the dam gene produces several phenotypes indicating multiple functions of methylation: (i) modulation of gene expression, (ii) DNA repair, (iii) initiation of replication, and (iv) stabilising the chromosome. |
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Authors:
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Abdelwaheb Chatti; Ahmed Landoulsi |
Publication Detail:
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Type: English Abstract; Journal Article; Review Date: 2008-07-02 |
Journal Detail:
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Title: Comptes rendus biologies Volume: 331 ISSN: 1631-0691 ISO Abbreviation: C. R. Biol. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-25 Completed Date: 2008-10-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140040 Medline TA: C R Biol Country: France |
Other Details:
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Languages: fre Pagination: 648-54 Citation Subset: IM |
Affiliation:
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Unité de biochimie des lipides et interaction des macromolécules en biologie, 03/UR/0902, faculté des sciences de Bizerte, Zarzouna 7021, Tunisie. chattiabdel@yahoo.fr |
Vernacular Title:
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L'état de la méthylation de l'ADN régule la virulence et la réponse au stress chez Salmonella. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenine
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chemistry Chromosomes, Bacterial / genetics, physiology DNA Methylation* DNA Repair DNA Replication / physiology DNA, Bacterial / genetics*, physiology* Escherichia coli / enzymology, genetics, metabolism Phenotype Salmonella / genetics*, pathogenicity* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Bacterial; 73-24-5/Adenine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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