Document Detail

The DNA-methylation state regulates virulence and stress response of Salmonella
MedLine Citation:
PMID:  18722983     Owner:  NLM     Status:  MEDLINE    
The DNA methylation is a post-replicative event that provides secondary information to that formed by DNA. Addition of this information involves DAM methyltransferase, which methylates DNA on specific sites (5'-GATC-3'). This modification of DNA may play a role in regulating various processes in eukaryote or prokaryote cells. It was well understood that deoxyadenosine methyltransferase (DAM) methylates the adenine of the GATC sequence. Following DNA replication, however, DNA is transiently hemimethylated, and the new strand is then methylated by DAM. In Escherichia coli, removing the dam gene produces several phenotypes indicating multiple functions of methylation: (i) modulation of gene expression, (ii) DNA repair, (iii) initiation of replication, and (iv) stabilising the chromosome.
Abdelwaheb Chatti; Ahmed Landoulsi
Publication Detail:
Type:  English Abstract; Journal Article; Review     Date:  2008-07-02
Journal Detail:
Title:  Comptes rendus biologies     Volume:  331     ISSN:  1631-0691     ISO Abbreviation:  C. R. Biol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-25     Completed Date:  2008-10-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140040     Medline TA:  C R Biol     Country:  France    
Other Details:
Languages:  fre     Pagination:  648-54     Citation Subset:  IM    
Unité de biochimie des lipides et interaction des macromolécules en biologie, 03/UR/0902, faculté des sciences de Bizerte, Zarzouna 7021, Tunisie.
Vernacular Title:
L'état de la méthylation de l'ADN régule la virulence et la réponse au stress chez Salmonella.
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MeSH Terms
Adenine / chemistry
Chromosomes, Bacterial / genetics,  physiology
DNA Methylation*
DNA Repair
DNA Replication / physiology
DNA, Bacterial / genetics*,  physiology*
Escherichia coli / enzymology,  genetics,  metabolism
Salmonella / genetics*,  pathogenicity*
Reg. No./Substance:
0/DNA, Bacterial; 73-24-5/Adenine

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