| DNA methylation: its contribution to systemic lupus erythematosus. | |
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MedLine Citation:
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PMID: 17061057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent studies on epigenetics, including the methylation of DNA and the enzymes regulating methylation, seem likely to contribute to understanding the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE). In fact, the relationship between DNA methylation and SLE has long been the subject of investigation. To obtain a deeper understanding of the role of DNA methylation in the onset of SLE, we reviewed the findings reported in the literature and our own data about DNA methylation and SLE. Various studies have indicated the possible importance of DNA methylation, especially hypomethylation, in the aetiology of SLE. Epigenetic studies may provide clues for elucidating the pathogenesis of SLE and for developing new strategies to treat this disease. |
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Authors:
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I Sekigawa; M Kawasaki; H Ogasawara; K Kaneda; H Kaneko; Y Takasaki; H Ogawa |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical and experimental medicine Volume: 6 ISSN: 1591-8890 ISO Abbreviation: Clin. Exp. Med. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-10-24 Completed Date: 2007-01-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100973405 Medline TA: Clin Exp Med Country: Italy |
Other Details:
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Languages: eng Pagination: 99-106 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu-shi, Chiba, 279-0021, Japan. sekigawa@juntendo-urayasu.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals CpG Islands DNA Methylation* Endogenous Retroviruses / genetics Epigenesis, Genetic Humans Lupus Erythematosus, Systemic / etiology, genetics*, metabolism* Mice Toll-Like Receptors / immunology Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Toll-Like Receptors |
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