| DNA methylation in neonates born to women receiving psychiatric care. | |
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MedLine Citation:
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PMID: 22419064 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prenatal exposure both to maternal psychiatric illness and psychiatric medication has been linked with adverse child outcomes that affect physiological, emotional and psychiatric development. Studies suggest that epigenetic mechanisms, such as DNA methylation, may facilitate these effects. In this report, we explore the association between maternal psychiatric illness and treatment during pregnancy and neonatal DNA methylation patterns in a prospectively-characterized clinical cohort of 201 dyads. Associations between the percent of umbilical cord blood DNA methylated at 27,578 CpG sites and maternal psychiatric diagnosis, symptoms and antidepressant use were evaluated by fitting a separate linear mixed effects model for each CpG site. There were no significant changes in neonatal DNA methylation attributable to maternal psychiatric diagnosis or depressive symptoms during pregnancy. Exposure to an antidepressant medication was associated with differential methylation of CpG sites in TNFRSF21 and CHRNA2 (false discovery rate < 0.05), but the average difference in methylation for both CpG sites was less than 3% between each group. The results were not specific to type of antidepressant or duration of the exposure. This study suggests that there are no large effects of maternal psychiatric illness, depressive symptoms or prenatal exposure to antidepressants on neonatal DNA methylation. Delineation of the influence of maternal psychiatric illness and pharmacological exposures on the developing fetuses has critical implications for clinical care during pregnancy. |
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Authors:
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James W Schroeder; Alicia K Smith; Patricia A Brennan; Karen N Conneely; Varun Kilaru; Bettina T Knight; D Jeffrey Newport; Joseph F Cubells; Zachary N Stowe |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-04-01 |
Journal Detail:
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Title: Epigenetics : official journal of the DNA Methylation Society Volume: 7 ISSN: 1559-2308 ISO Abbreviation: Epigenetics Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-05-23 Completed Date: 2012-09-14 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 101265293 Medline TA: Epigenetics Country: United States |
Other Details:
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Languages: eng Pagination: 409-14 Citation Subset: IM |
Affiliation:
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Genetics and Molecular Biology Program, Emory University, Atlanta, GA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antidepressive Agents
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adverse effects,
pharmacology* Antiemetics / adverse effects, pharmacology Bupropion / adverse effects, pharmacology CpG Islands DNA Methylation* Depressive Disorder, Major / drug therapy, pathology Female Fetal Blood / cytology, drug effects*, metabolism Genome, Human / drug effects* Humans Hypnotics and Sedatives / adverse effects, pharmacology Infant, Newborn / blood*, metabolism Male Pregnancy Prenatal Exposure Delayed Effects / genetics, metabolism, pathology Prospective Studies Receptors, Nicotinic / genetics, metabolism Receptors, Tumor Necrosis Factor / genetics, metabolism Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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K01 MH085806/MH/NIMH NIH HHS; MH085806/MH/NIMH NIH HHS; P50 MH077928/MH/NIMH NIH HHS; P50 MH68036/MH/NIMH NIH HHS; RC1 MH088609/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Antiemetics; 0/CHRNA2 protein, human; 0/Hypnotics and Sedatives; 0/Receptors, Nicotinic; 0/Receptors, Tumor Necrosis Factor; 0/TNFRSF21 protein, human; 34841-39-9/Bupropion |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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