Document Detail


DNA methylation in neonates born to women receiving psychiatric care.
MedLine Citation:
PMID:  22419064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prenatal exposure both to maternal psychiatric illness and psychiatric medication has been linked with adverse child outcomes that affect physiological, emotional and psychiatric development. Studies suggest that epigenetic mechanisms, such as DNA methylation, may facilitate these effects. In this report, we explore the association between maternal psychiatric illness and treatment during pregnancy and neonatal DNA methylation patterns in a prospectively-characterized clinical cohort of 201 dyads. Associations between the percent of umbilical cord blood DNA methylated at 27,578 CpG sites and maternal psychiatric diagnosis, symptoms and antidepressant use were evaluated by fitting a separate linear mixed effects model for each CpG site. There were no significant changes in neonatal DNA methylation attributable to maternal psychiatric diagnosis or depressive symptoms during pregnancy. Exposure to an antidepressant medication was associated with differential methylation of CpG sites in TNFRSF21 and CHRNA2 (false discovery rate < 0.05), but the average difference in methylation for both CpG sites was less than 3% between each group. The results were not specific to type of antidepressant or duration of the exposure. This study suggests that there are no large effects of maternal psychiatric illness, depressive symptoms or prenatal exposure to antidepressants on neonatal DNA methylation. Delineation of the influence of maternal psychiatric illness and pharmacological exposures on the developing fetuses has critical implications for clinical care during pregnancy.
Authors:
James W Schroeder; Alicia K Smith; Patricia A Brennan; Karen N Conneely; Varun Kilaru; Bettina T Knight; D Jeffrey Newport; Joseph F Cubells; Zachary N Stowe
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-04-01
Journal Detail:
Title:  Epigenetics : official journal of the DNA Methylation Society     Volume:  7     ISSN:  1559-2308     ISO Abbreviation:  Epigenetics     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-05-23     Completed Date:  2012-09-14     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101265293     Medline TA:  Epigenetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  409-14     Citation Subset:  IM    
Affiliation:
Genetics and Molecular Biology Program, Emory University, Atlanta, GA, USA.
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MeSH Terms
Descriptor/Qualifier:
Antidepressive Agents / adverse effects,  pharmacology*
Antiemetics / adverse effects,  pharmacology
Bupropion / adverse effects,  pharmacology
CpG Islands
DNA Methylation*
Depressive Disorder, Major / drug therapy,  pathology
Female
Fetal Blood / cytology,  drug effects*,  metabolism
Genome, Human / drug effects*
Humans
Hypnotics and Sedatives / adverse effects,  pharmacology
Infant, Newborn / blood*,  metabolism
Male
Pregnancy
Prenatal Exposure Delayed Effects / genetics,  metabolism,  pathology
Prospective Studies
Receptors, Nicotinic / genetics,  metabolism
Receptors, Tumor Necrosis Factor / genetics,  metabolism
Time Factors
Grant Support
ID/Acronym/Agency:
K01 MH085806/MH/NIMH NIH HHS; MH085806/MH/NIMH NIH HHS; P50 MH077928/MH/NIMH NIH HHS; P50 MH68036/MH/NIMH NIH HHS; RC1 MH088609/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Antidepressive Agents; 0/Antiemetics; 0/CHRNA2 protein, human; 0/Hypnotics and Sedatives; 0/Receptors, Nicotinic; 0/Receptors, Tumor Necrosis Factor; 0/TNFRSF21 protein, human; 34841-39-9/Bupropion
Comments/Corrections

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