Document Detail


DNA methylation defects in sporadic and hereditary colorectal cancer.
MedLine Citation:
PMID:  22459641     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
DNA methylation is a fundamental epigenetic mechanism in regulating the expression of genes controlling crucial cell functions in cancer development. Methylation defects (both global hypomethylation and hypermethylation of CpG islands) are implicated in colorectal carcinogenesis. Some nutrients have a clear effect on methylation, suggesting that some dietary-associated differences in the incidence of colorectal cancer could be due to the effect of diet on methylation. The presence of methylation defects has clear diagnostic and prognostic implications. Thus, several tests are being used for colorectal cancer screening based on methylated gene analysis, whether in feces or blood. In addition, the reversibility of methylation processes allows the development of chemotherapies that regulate this process through their antineoplastic activity.
Authors:
Rosa M Xicola; Xavier Llor
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-27
Journal Detail:
Title:  Gastroenterologia y hepatologia     Volume:  -     ISSN:  0210-5705     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406671     Medline TA:  Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  SPA     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier España, S.L. y AEEH y AEG. All rights reserved.
Affiliation:
Univerisity of Illinois at Chicago, Digestive Disease and Nutrition, Chicago, EE. UU.
Vernacular Title:
Defectos de la metilación del ADN en el cáncer colorrectal esporádico y hereditario.
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