Document Detail

DNA methylation changes during mouse spermatogenesis.
MedLine Citation:
PMID:  8032673     Owner:  NLM     Status:  MEDLINE    
Genomic imprinting in mammals is thought to be mediated by differences in the methylation level of cytosine residues in the genome. These differences in DNA methylation are thought to be generated during the development of the germ line. To characterize the profile of global methylation of the mouse genome during male gametogenesis, we have quantified the relative level of methylation in individual cells during meiosis and spermatogenesis. A decrease in the level of DNA methylation is observed from meiotic cells to elongated spermatids. The erasure of the somatic pattern of methylation during spermatogenesis suggests the existence of a subsequent mechanism generating the parental specific methylation patterns leading to genomic imprinting of specific alleles.
J del Mazo; G Prantera; M Torres; M Ferraro
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology     Volume:  2     ISSN:  0967-3849     ISO Abbreviation:  Chromosome Res.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-08-15     Completed Date:  1994-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9313452     Medline TA:  Chromosome Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  147-52     Citation Subset:  IM    
Centro de Investigaciones Biológicas (C.S.I.C.), Madrid, Spain.
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MeSH Terms
DNA / chemistry*
DNA (Cytosine-5-)-Methyltransferase / metabolism
Gene Expression Regulation
Models, Genetic
Sertoli Cells / chemistry,  ultrastructure
Spermatids / chemistry,  ultrastructure
Spermatogonia / chemistry,  ultrastructure
Reg. No./Substance:
9007-49-2/DNA; EC (Cytosine-5-)-Methyltransferase

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