| DNA measurements by single nuclei flow cytometry in human actinic skin lesions. | |
| | |
MedLine Citation:
|
PMID: 7310165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A basal cell carcinoma, a Bowenoid carcinoma and clinically normal nonexposed skin from a 76-yr-old male with numerous epidermal tumors on sun-damaged skin were investigated by DNA flow cytometry and the results were compared with data obtained from normal skin of a control group. From each type of skin lesion 3 different biopsies were examined. Each of the DNA frequency distribution histograms showed bimodal configuration revealing no more than one DNA stem line, which was diploid in the unaffected skin and the Bowen carcinoma and hyperdiploid in the basal cell carcinoma. The 3 different types of skin could be clearly separated by means of at least 1 of 3 parameters: S-fraction, G2 + M fraction or S/G2 + M index. The S/G2 + M index came out as the most sensitive discriminator for the tumors. The S-fraction level was higher in the clinically normal skin of the investigated male than in the control group and further high in the tumors. |
| | |
Authors:
|
G Frentz; U Møller |
Related Documents
:
|
3115615 - Sequential studies of skin tumorigenesis in pgk mosaic mice: the effect of repeated exp... 15976015 - Inhibitory effects of 12-o-tetradecanoylphorbol-13-acetate alone or in combination with... 10885405 - Cell proliferation in skin tumors with ductal differentiation: patterns and diagnostic ... 20336085 - Incidence and trends of cutaneous malignancies in the netherlands, 1989-2005. 2909685 - Primary optic nerve sheath meningiomas. report of nine cases. 21080955 - Loss of heterozygosity and sostdc1 in adult and pediatric renal tumors. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of investigative dermatology Volume: 77 ISSN: 0022-202X ISO Abbreviation: J. Invest. Dermatol. Publication Date: 1981 Dec |
Date Detail:
|
Created Date: 1982-02-12 Completed Date: 1982-02-12 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 431-3 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Carcinoma, Basal Cell / pathology Carcinoma, Squamous Cell / pathology Cell Cycle Cell Nucleus / analysis* DNA / analysis* Flow Cytometry / methods* Humans Male Skin / analysis* Skin Neoplasms / analysis, pathology* |
| Chemical | |
Reg. No./Substance:
|
9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sub-costal xypho-umbilico flap. A new approach to the neoplastic kidney (author's transl)
Next Document: Ultraviolet light sensitivity and prolonged UVR-erythema.